Neural circuits function in the face of changing inputs, either caused by normal variation stimuli or cell death. To maintain their ability to perform essential computations with partial neural make modifications. Here, we study retinal circuit’s responses changes light photoreceptor inputs inducing cone death mature mouse retina. Can retina withstand recover from input loss? We find that excit...

Despite language disabilities in autism, music abilities are frequently preserved. Paradoxically, brain regions associated with these functions typically overlap, enabling investigation of neural organization supporting speech and song in autism. Neural systems sensitive to speech and song were compared in low-functioning autistic and age-matched control children using passive auditory stimulat...

Whether hESC Q:3 -derived neurons can fully integrate with and functionally regulate an existing neural network remains unknown. Here, we demonstrate that hESC-derived neurons receive unitary postsynaptic currents both in vitro and in vivo and adopt the rhythmic firing behavior of mouse cortical networks via synaptic integration. Optical stimulation of hESC-derived neurons expressing Channelrho...

Abstract Neurodegenerative diseases, such as Alzheimer’s disease, constitute a major socioeconomic burden. As clinical prevalence dramatically increases, the need for disease-modifying therapies is pressing. In this context, regenerative medicine are considered promising strategy treatment of these patients, due to low turnover neural tissues and extensive neurodegeneration. The transplant exog...

One challenge in contemporary neuroscience is to achieve an integrated understanding of the large-scale brain-wide interactions, particularly the spatiotemporal patterns of neural activity that give rise to functions and behavior. At present, little is known about the spatiotemporal properties of long-range neuronal networks. We examined brain-wide neural activity patterns elicited by stimulati...

Functional magnetic resonance imaging (fMRI) is a noninvasive tool used to probe cognitive and affective processes. Although fMRI provides indirect measures of neural activity, the advent of fMRI has allowed for1) the corroboration of significant animal findings in the human brain, and2) the expansion of models to include more common human attributes that inform behavior. In this review, we bri...

BACKGROUND A small but increasing number of studies suggest that non-invasive brain stimulation by means of transcranial direct current stimulation (tDCS) can modulate arithmetic processes that are essential for higher-order mathematical skills and that are impaired in dyscalculic individuals. However, little is known about the neural mechanisms underlying such stimulation effects, and whether ...

The recent application of neurostimulation techniques to enhance the understanding of swallowing neural plasticity has expanded the focus of rehabilitation research from manipulation of swallowing biomechanics to manipulation of underlying neural systems. Neuromodulatory strategies that promote the brain's ability to reorganize its neural connections have been shown to hold promising potential ...

Multi-functional neural probes integrated with various stimulation modalities are becoming essential tools in neuroscience to study the brain more effectively. In this paper, we present a new multi-functional neural probe that allows chemical stimulation through drug delivery and simultaneous recording of individual neuron signals through a microelectrode array. By embedding microchannels in si...

Neural circuits often face the problem of classifying stimuli into discrete groups and making decisions based on such classifications. Neurons of these circuits can be distinguished according to their correlations with different features of stimulus or response, which allows defining sensory or motor neuronal types. In this study we define the third class of neurons, which is responsible for ma...