background: allergy to saffron (crocus sativus) pollen has been described in people involved in processing of saffron flower stamens. profilins have been identified as a pan-allergen in different plant pollens and foods. this molecule is an actin-binding pro-tein with a molecular weight of 12-16 kda found in eukaryotic species. objective: the aim of this study was to generate monoclonal antibod...

BACKGROUND Rat allergen has proved to be an important cause of IgE-mediated hypersensitivity in the occupational setting. The prevalence and significance of rat allergen in homes has not been studied. OBJECTIVE The purpose of this study was to determine the prevalence of rat allergen in the homes of inner-city children with asthma and to examine the relationship between rat allergen exposure,...

Aspergillus fumigatus is a filamentous fungal saprophyte that is ubiquitous in the environment. It is also a human pathogen and induces allergenic response, negatively impacting health care and associated costs significantly around the world. Much of the basic biology of this organism is only poorly understood, but the recent completion and publication of its genome sequence provides an excelle...

In 1873, Charles Harrison Blackley recognised pollen as the cause of hay fever and ‘‘hay asthma’’ [1]. For the first time, he collected pollen grains with a kite that had a sticky tail and then he counted them. Being affected by seasonal asthma himself, he also performed the first skin prick test on his own arm. Since then, aerobiology (from Greek á r, aēr, ‘‘air’’; bioz, bios, ‘‘life’’; and -l...

abstract the genus aspergillus, which consists of a few hundred opportunistic mold species found in various climatic conditions, causes diseases including localized infections, fatal diseases, allergic responses, and inhaled conidia in humans. herein, we present an overview of the most common diseases and allergic infections caused by aspergillus species and their associated health hazards in v...

the prevalence of allergic disorders has increased markedly throughout the world over the past three decades. it seems probable that the increased prevalence is real because longitudinal studies have shown a rapid exponential increase in allergic disor¬ders. in order to determine the prevalence of type 1 allergy in patients with allergic disorders in sistan-blouchestan province, in the southeas...

BACKGROUND Allergen induced early phase airway response and airway plasma exudation are predominantly mediated by inflammatory mast cell mediators including histamine, cysteinyl leukotrienes (cysLTs) and thromboxane A2 (TXA2). The aim of the present study was to evaluate whether repeated allergen exposure affects early phase airway response to allergen challenge. METHODS A trimellitic anhydri...

BACKGROUND Exposure to airborne wheat allergen is a well-known cause of bakers' allergy and asthma. Airborne wheat allergen can be measured by enzyme immunoassays (EIAs) in extracts of inhalable dust samples, but only limited knowledge is available on the size distribution of wheat allergen-carrying particles. Recently, a new sampling medium, porous polyurethane foam, has been introduced for th...

Objective(s):Sublingual allergen-specific immunotherapy is a safe and effective method for treatment of IgE-mediated respiratory allergies; however, the underlying mechanisms are not fully understood. This study was planned to test whether sublingual immunotherapy (SLIT) can exert epigenetic mechanisms through which the airway allergic responses can be extinguished. Materials and Methods:BALB/c...