نتایج جستجو برای: fungal drug resistance
تعداد نتایج: 954025 فیلتر نتایج به سال:
Infections caused by opportunistic fungal pathogens have reached concerning numbers due to the increase of the immunocrompromised human population and to the development of antifungal resistance. This resistance is often attributed to the action of multidrug efflux pumps, belonging to the ATP-binding cassette (ABC) superfamily and the major facilitator superfamily (MFS). Although many studies h...
objective: the use of antiretroviral drugs has proven remarkably effective in controlling the progression of human immunodeficiency virus (hiv) disease, but these benefits can be compromised by the development of drug resistance. this study aims to assess the drug resistance profile of the pr gene in highly active antiretroviral therapy (haart)-treated and naïve hiv-1 infected patients. metho...
objectives in this study, we explored a physical method of converting drug-resistant bacteria to drug-sensitive ones. materials and methods this is an in vitro case-control study, performed at the ionizing and non-ionizing radiation protection research center (inirprc), shiraz university of medical sciences (sums), shiraz, iran in 2014. all experiments were carried out using gram-negative bacte...
conclusions these findings underscored the importance of monitoring and developing guidelines for better management of infectious diarrhoea in bangladesh and elsewhere. background diarrhoea is considered as the most widespread illness occurring in bangladesh. in addition, the growing antimicrobial resistance of diarrhoeal pathogens in this developing country hardens physicians to supervise pati...
Treatment of fungal infections is difficult due to several reasons, such as side effects of drugs, emergence of resistant strains, and limited number of molecular targets for the drug compounds. In fungi, heat shock proteins (Hsps) have been implicated in several processes with the conserved molecular chaperone Hsp90 emerging as a potential target for antifungal therapy. It plays key cellular r...
The unusual amino acid l-cyclopropylalanine was isolated from the mushroom Amanita virgineoides after detection in an anti-fungal screening test. l-Cyclopropylalanine was found to exhibit broad-spectrum inhibition against fungi and bacteria. The anti-fungal activity was found to be abolished in the presence of the amino acid l-leucine, but not any other amino acids, indicating that l-cyclopropy...
Fungal pathogens represent a leading cause of life-threatening infections in debilitated patients and exert a substantial toll on health care resources. A major development in the past few years, resulting from extremely rapid technological advances, has been the elucidation of the genome sequences of all of the major human fungal pathogens. Together with the development of transcriptomics and ...
UNLABELLED Recent estimates suggest that >300 million people are afflicted by serious fungal infections worldwide. Current antifungal drugs are static and toxic and/or have a narrow spectrum of activity. Thus, there is an urgent need for the development of new antifungal drugs. The fungal sphingolipid glucosylceramide (GlcCer) is critical in promoting virulence of a variety of human-pathogenic ...
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