One of the major mechanisms by which measles virus (MV) infection causes disease and death is suppression of the immune response. The nonresponsiveness of MV-infected human lymphocytes to mitogens and a partial block in the G0/G1 phase of the cell cycle observed in vitro is thought to reflect in vivo immunosuppression. In order to molecularly dissect MV-induced immunosuppression, we analyzed ex...

Many viruses exploit the host cell division cycle to favour their own growth. Here we demonstrated that porcine circovirus type 2 (PCV2), which is a major causative agent of an emerging and important swine disease complex, PCV2-associated diseases, caused G0/G1 cell cycle arrest through degradation of cyclin D1 and E followed by reduction of retinoblastoma phosphorylation in synchronized PCV2-i...

Let M0 = G0/H be a (pseudo)-Riemannian homogeneous spin manifold, with reductive decomposition g0 = h + m and let S(M0) be the spin bundle defined by the spin representation Ãd : H → GLR(S) of the stabilizer H . This article studies the superizations of M0, i.e. its extensions to a homogeneous supermanifold M = G/H whose sheaf of superfunctions is isomorphic to Λ(S(M0)). Here G is the Lie super...

For undirected graphs G (V, E) and G0 (V0 , E0), say that G is a region intersection graph over G0 if there is a family of connected subsets {Ru ⊆ V0 : u ∈ V} of G0 such that {u , v} ∈ E ⇐⇒ Ru ∩ Rv , ∅. We show if G0 excludes the complete graph Kh as a minor for some h > 1, then every region intersection graph G over G0 with m edges has a balanced separator with at most ch √ m nodes, where ch i...

DNA double strand breaks (DSBs) elicit prompt activation of DNA damage response (DDR), which arrests cell-cycle either in G1/S or G2/M in order to avoid entering S and M phase with damaged DNAs. Since mammalian tissues contain both proliferating and quiescent cells, there might be fundamental difference in DDR between proliferating and quiescent cells (or G0-arrested). To investigate these diff...

The angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis is a pathway that acts against the detrimental effects of the renin-angiotensin system. However, the effects of angiotensin-(1-7) on endothelial protein expression and the related phenotypes are unclear. We performed a duplicate of iTRAQ quantitative proteomic analysis on human aortic endothelial cells (HAECs) treated with angiotens...

The effects of tamoxifen on cell cycle progression and clonogenic survival have been examined using synchronized cultures of MCF-7 human mammary carcinoma cells. Cell synchrony was induced by mitotic selection. Subsequent cell cycle analyses, using DNA flow cytometry, showed that 85% of synchronized cells had a mean cell cycle time of 21.3 hr with mean phase durations of 9 hr for G0-G1, 9.3 hr ...

A bstract . Let G0 be a real semisimple Lie group, let R be a parabolic subgroup of the complexification G of G0 , let D be an open G0-orbit in the complex flag manifold X = G/R, and let Y be a maximal compact linear subvariety of D. First, an explicit parabolic subgroup Q ⊂ R ⊂ G is constructed so that the open G0-orbits on W = G/Q are measurable and one such orbit D̃ = G0(w) ⊂ W maps onto D wi...

The treatment of human myeloid leukemia cell lines with phorbol esters, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), is associated with loss of proliferative capacity and induction of monocytic differentiation. The present results demonstrate that treatment of asynchronous human U-937 leukemia cells with 10 nM TPA is also associated with oligonucleosomal DNA cleavage. This pattern of DNA...

1. The G0 dichotomy A digraph (or directed graph) on a set X is a subset G ⊆ X \ ∆. Given a digraph G on a set X and a subset A ⊆ X, we say that A is G-discrete if for all x, y ∈ A we have (x, y) / ∈ G. Now let sn ∈ 2 be chosen for every n ∈ N such that ∀s ∈ 2<N ∃n s v sn. Then we can define a digraph G0 on 2N by G0 = {(sn0x, sn1x) ∈ 2N × 2N ∣∣ n ∈ N & x ∈ 2N}. Lemma 1. If B ⊆ 2N has the Baire ...