characterized by thrombus formation in the hepatic vein.1 Untreated, prognosis is generally poor. The main interventions are construction of an operative shunt and orthotopic liver transplantation.2 The prothrombin 20210 G to A mutation (G20210A) has been shown to cause spontaneous production of fibrin and an increased risk of thrombosis. This mutation may have caused cases of Budd-Chiari syndr...

Inflammatory bowel diseases are associated with increased risk for thrombotic complications, In patients with ulcerative colitis (UC) cerebral sinus venous thrombosis (CSVT) is an extremely rare complication. We report a patient with active UC and CSVT. The patient was heterozygous for Factor V Leiden and G20210A prothrombin gene mutations without other identifiable precipitating factors. This ...

Aim: This study aimed to investigate the relationship between severe novel coronavirus pneumonia (NCP) and hypercoagulable conditions that predispose patients thrombosis such as prothrombin gene ( F2) rs1799963 (G20210A), factor V Leiden F5) rs6025 (G1691A) PAI-1 (rs1799768). Patients: NCP-diagnosed 62 previously healthy were enrolled for investigation of thrombophilia-related polymorphisms. Ma...

BACKGROUND The thrombin-generation assay has a variety of clinical uses, including diagnosis of thromboembolism-related disease, and particular profiles are associated with thrombophilic risk factors. The aim of this study was to evaluate the use of this assay in screening and identifying patients who require specific thrombophilic testing. METHODS We used a 2-step approach to perform specifi...

BACKGROUND The association between the inherited gene mutations of factor V, prothrombin, and homocysteine metabolism and venous thromboembolic events is accepted widely; however, their influence on the arterial circulatory system remains controversial. METHODS We performed a MEDLINE search to identify published case-control and cohort studies correlating the factor V Leiden, prothrombin (PT)...