نتایج جستجو برای: gadolinium dtpa
تعداد نتایج: 13816 فیلتر نتایج به سال:
Gadolinium-Incorporated Carbon Nanodots for <i>T</i><sub>1</sub>-Weighted Magnetic Resonance Imaging
The design and development of contrast agents for magnetic resonance imaging (MRI) with improved chemical stability higher contrasting capability clinical translation compared to conventional are still great interest. In this study, a facile universal approach was explored controllable functionalization red-emissive carbon nanodots (RCNDs) diethylenetriaminepentaacetic anhydride (DTPA) chelatio...
Purpose: In epiphora, dacryocystography (DCG) is established for localization of underlying dacryostenosis. DCG is of limited value concerning the depiction of periductal structures, and does not provide functional information e.g. in dysfunction of the canalicular muscle pump or relative stenoses for reasons of active instillation of the contrast agent. Dacryoszintigraphy provides sufficient f...
MRI measurements of water diffusion and blood perfusion are increasingly used for the evaluation of organ functionality and tissue viability (e.g., in tumors). While diffusion-weighted imaging is performed without contrast agents, measurement of blood perfusion is normally performed based on the administration of paramagnetic substances such as gadolinium diethylenetriamine pentaacetic acid (Gd...
Elevated interstitial fluid pressure (IFP) in tumors can cause metastatic dissemination and treatment resistance, but its study poses a challenge because of a paucity of noninvasive imaging strategies. In this study, we address this issue by reporting the development of a noninvasive tool to assess tumor IFP and interstitial hypertension-induced lymph node metastasis. Using mouse xenograft mode...
The synthesis and relaxivity properties of a new dendrimeric Gd chelate, Gd-TREN-bisHOPO-TAM-Asp-Asp2-12OH, are presented. The macromolecule demonstrates improved water solubility due to its 12 terminal hydroxyl groups and improved relaxivity due to its optimal water exchange rate and slower molecular tumbling. Unprecedented high relaxivity (r1p = 18 mM-1 s-1) is observed at high magnetic field...
BACKGROUND Natalizumab, a humanized monoclonal IgG4 antibody, is an alpha4-integrin antagonist, which inhibits the migration of inflammatory cells into the central nervous system, a key pathogenic mechanism in multiple sclerosis (MS). In a six month, phase II clinical trial of patients with relapsing MS, natalizumab significantly reduced the formation of new gadolinium-enhanced (Gd+) lesions an...
Gd-HPDO3A has been internalized into rat hepatocarcinoma cells in the cytoplasm (by electroporation) or in intracellular vesicles (by pinocytosis), respectively. In the former case, the observed relaxation rates are likely dependent upon the amount of internalized paramagnetic complex, whereas in the latter case the relaxation enhancement is "quenched" to a plateau value (about 3 s(-1)) when th...
OBJECTIVE We aimed to investigate the natural outcome of nonhypervascular lesions detected in the hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI by performing a longitudinal study retrospectively enrolled in a nationwide manner. METHODS Between February 2008 and March 2011, 224 patients with 504 nodules that were diagnosed as nonh...
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