Glucan particles (GPs) are hollow, porous 3-5 μm microspheres derived from the cell walls of Baker's yeast (Saccharomyces cerevisiae). The 1,3-β-glucan outer shell provides for receptor-mediated uptake by phagocytic cells expressing β-glucan receptors. GPs have been used for macrophage-targeted delivery of a wide range of payloads (DNA, siRNA, protein, small molecules, and nanoparticles) encaps...

BACKGROUND Prostate cancer is biologically and clinically a heterogeneous disease that makes imaging evaluation challenging. One of the important challenges in this cancer is to detect recurrent disease. Biochemical response using Prostate Specific Antigen (PSA) and Imaging using several PET tracers have poor sensitivity and specificity. Therefore, we analyse the role of Ga68-PSMA (Prostate Spe...

Combination chemotherapy forms the backbone of cancer treatment. There is a need for new drug combinations for the treatment of mantle cell lymphoma (MCL). Herein, we show that gallium maltolate, a novel gallium compound, synergizes with bortezomib, a proteasome inhibitor, to induce cell death in MCL Granta cells. Cells exposed to either agent displayed caspase-3 activation, a loss of mitochond...

Articles you may be interested in A thermalization energy analysis of the threshold voltage shift in amorphous indium gallium zinc oxide thin film transistors under simultaneous negative gate bias and illumination Instability of amorphous hafnium-indium-zinc-oxide thin film transistors under negative-bias-illumination stress Appl. Investigation of zinc interstitial ions as the origin of anomalo...

The reasons why aminoglycosides are bactericidal have not been not fully elucidated, and evidence indicates that the cidal effects are at least partly dependent on iron. We demonstrate that availability of iron markedly affects the susceptibility of the facultative intracellular bacterium Francisella tularensis strain SCHU S4 to the aminoglycoside gentamicin. Specifically, the intracellular dep...

A series of molecular gallium compounds were analyzed using X-ray photoelectron spectroscopy (XPS). Specifically, the Ga 2p3/2 and Ga 3d5/2 photoelectron binding energies and the Ga L3M45M45 Auger electron kinetic energies of compounds with gallium in a range of assigned oxidation numbers and with different stabilizing ligands were measured. Auger parameters were calculated and used to generate...

The melting point of gallium (29.7646 °C) is a defining thermometric fixed point of the International Temperature Scale of 1990 (ITS-90). Realization of this melting point is performed using a fixedpoint cell containing high-purity (≥99.999 99 wt. % pure) gallium. A 30 kg single lot of gallium (99.999 9956 wt. % pure) constituting Standard Reference Material (SRM) 1751 was evaluated, and certif...

Gallium 67 citrate was evaluated with conventional scanning and emission computed tomography (CT) scanning as a method of pretreatment staging of the intrathoracic, especially mediastinal, spread of lung cancer. Of 31 patients with tumours of various histological types, the isotope was concentrated in the primary lesion in all but one. In 10 out of 12 patients who underwent surgical exploration...

We present the case of an 11 year-old Caucasian girl who presented chest pain of 12 weeks evolution, with no other symptoms and a negative physical examination. Lactate dehydrogenase levels were increased to 797 U/l, whereas beta-2-microglobulin (BM2) levels were normal. The thoracic CT showed a bulky mediastinal mass that occupied the pretracheal, paratracheal and right prevascular regions. Th...

A structural transformation induced by optical impulse excitation of only a few mJ/cm fluence affecting the nanoscale surface melt layer of gallium at a ZnSe–gallium interface leads to a fast, substantial and fully reversible change in reflectivity of up to 50%. Recovery occurs within a few ls after excitation is withdrawn and less than 1 ls at temperatures more than 4 K below gallium s melting...