Rodent mast cells (MCs) are reported to play a pivotal role in both innate and adaptive immunity. However, there is so far no evidence that human MCs are involved in innate immunity. We found that a functional Toll-like receptor 4 (TLR4) was expressed on human MCs when it was up-regulated by interferon gamma (IFN-gamma). To systematically explore how human MCs modulate the immune system followi...

Observations suggest that the dark matter and stars in early-type galaxies `conspire' to produce a surprisingly simple distribution of total mass, $\rho(r)\propto\rho^{-\gamma}$, with $\gamma\approx2$. We measure mass 48 gravitationally lens resolved background source. By fitting source light every pixel images from Hubble Space Telescope, we find mean $\langle\gamma\rangle=2.075_{-0.024}^{+0.0...

The effects exerted on the in vitro development of antigen-specific T cell lines and T cell clones by addition or neutralization of interleukin 12 (IL-12) in lymphocyte bulk culture were examined. T cell lines specific for Dermatophagoides pteronyssinus group I (Der p I) derived in the presence of IL-12 exhibited reduced ability to produce IL-4 and increased ability to produce interferon gamma ...

In this paper, we present in-depth analysis of the condensation energy $E_c$ for a superconductor in situation when superconductivity emerges out non-Fermi liquid due to pairing mediated by massless boson. This is case electronic-mediated near quantum-critical point metal, SYK-type models, and phonon-mediated properly defined limit, dressed Debye frequency vanishes. We consider subset these whi...

PURPOSE To investigate various issues for clinical implementation of aSi EPID panels for IMRT/VMAT QA. METHODS Six linacs are used in our clinic for EPID-based plan QA; two Varian Truebeams, two Varian 2100 series, two Elekta Infiniti series. Multiple corrections must be accounted for in the calibration of each panel for dosimetric use. Varian aSi panels are calibrated with standard dark fiel...

To further understand the role of neuro-immunological interactions in the pathogenesis of rheumatoid arthritis (RA), we studied the influence of sympathetic neurotransmitters on cytokine production of T cells in patients with RA. T cells were isolated from peripheral blood of RA patients or healthy donors (HDs), and stimulated via CD3 and CD28. Co-incubation was carried out with epinephrine or ...

Inhibition of gamma-secretase, one of the enzymes responsible for the cleavage of the amyloid precursor protein (APP) to produce pathogenic A beta peptides, is an attractive approach for the treatment of Alzheimer's disease. We have designed a new gamma-secretase thiazolamide inhibitor bearing a dihydronicotinoyl moiety as Redox Delivery System which allows specific delivery of the drug to the ...

Introduction The Gamma Knife system is designed solely for non-invasive treatment of brain disorders, and it benefits from stereotactic surgical techniques. Dose calculations required in the system are performed by GammaPlan code; in this code, brain tissue is considered uniform. In the present study, we evaluated the effect of Gamma Knife system on the obtained dose through simulating a real ...