Export of mRNA from the nucleus is a central process in eukaryotic gene expression that has been implicated in several human diseases. Much of our understanding of how an mRNA is transported to the cytoplasm is derived from studies using yeast and fly models. We present here different mechanisms by which aberrant nuclear retention of mRNA can cause human disease. Emerging evidence that implicat...

In eukaryotic cells, the nuclear membrane creates a barrier between the nucleus and the cytoplasm. Whereas RNA synthesis occurs in the nucleus, they mostly function in the cytoplasm; thus export of RNA molecules from the nucleus to the cytoplasm is indispensable for normal function of the cells. The molecular mechanisms involved in each kind of cellular RNA export is gradually understood. The f...

SUMMARY Morocco is a privileged partner of the European Union. The EU is Morocco's most important export market, its leading public and private external investor and its most important tourist market. Morocco also contributes to the EU's energy security as a strategic transit country for Algerian gas and as an exporter of electricity to Spain. Human exchanges are constantly expanding: the EU is...

a diversification of the country’s export structure through the concerted development of its export-oriented manufacturing capacity could offer a viable alternative, as also stipulated in the country’s second socioeconomic and cultural development plan, by increasing the resilience of its economy against external shocks, supporting employment creation and technological innovation, and adding do...

raisin is the second major export item in iranian agricultural section after pistachio. in this study, effects of exchange rate fluctuations were investigated on quantity and price of exported raisin. therefore, data of 1970 to 2008 were reviewed by time series analysis and estimated by auto-regressive distributed lag model (ardl). results show the absence of a long-term relationship between ex...

Hydrogen is getting increasing attention by government and industry leaders, [1], as a very environmentally attractive and clean fuel because its oxidation leads only to water formation. There is abundance of hydrogen in nature, although it is only available for exploitation in a combined state, either in water, hydrocarbons, or coal [2]. Its recovery from these natural resources requires the a...

This study aims at comparing the economic relations of Japan with Iran and with Saudi Arabia. The comparison of these two relations is important as Iran and Saudi Arabia are leading exporters and Japan is a large importer of crude oil in the world. After a brief overview of the history of these two relations, the criteria of trade complementarity, i.e. Trade Potential Naive Assessment, Cosine M...

Several factors contribute to nuclear mRNA export in Saccharomyces cerevisiae, including Mex67p, Mtr2p, Gle1p, Nup159p, Dbp5p, and Rip1p. Strains carrying mutations in these factors show rapid and dramatic nuclear accumulation of poly(A)(+) RNA. We have characterized two heat shock mRNAs, SSA4 and HSP104, in these mutant backgrounds; each transcript concentrates in a single intranuclear focus. ...

Paleoatmospheric records of trace-gas concentrations recovered from ice cores provide important sources of information on many biogeochemical cycles involving carbon, nitrogen, and oxygen. Here, we present a 106,000-year record of atmospheric nitrous oxide (N2O) along with corresponding isotopic records spanning the last 30,000 years, which together suggest minimal changes in the ratio of marin...

The onset of export during leaf development was correlated with changes in metabolism and ultrastructure and with patterns of solute distribution in the developing seventh leaf of sugar beet (Beta vulgaris L.) in order to study the cause of initiation of translocation. Infrared gas analysis of carbon dioxide uptake showed a broad peak for net photosynthesis dm(-2) at 35 to 40% final laminar len...