The GPSS-FORTRAN simulator is a Fortran program package suitable for modelling discrete systems. It consists of a chassis, the main program, into which calls to the modules, GPSS-FORTRAN's subroutines are inserted. Its construction makes it superior in several respects to its grandparent, GPSS. Other simulation languages and tools for the analysis of discrete systems such as SIMULA, SIMSCRIPT a...

The World Health Organization Western Pacific Region Gonococcal Antimicrobial Surveillance Programme (WHO WPR GASP) examined approximately 8,400 isolates of Neisseria gonorrhoeae from 16 countries for resistance to relevant antibiotics in 2006. Antimicrobial resistance was at record levels in the region and poses major problems for the management of this important disease. High rates of resista...

OBJECTIVE The pathogenesis of painful diabetic neuropathy (PDN) is not clear. Following our in vivo observations of increased sural nerve epineurial blood flow in patients with PDN, we investigated the cutaneous microcirculation of the foot by laser Doppler flowmetry to determine if the epineurial findings were just confined to the nerve or more widespread in other vascular beds. RESEARCH DES...

The purpose of this study was to longitudinally assess the behavioral and electrophysiological hearing changes of a girl inserted in a CI program, who had bilateral profound sensorineural hearing loss and underwent surgery of cochlear implantation with electrode activation at 21 months of age. She was evaluated using the P1 component of Long Latency Auditory Evoked Potential (LLAEP); speech per...

Vibrio fischeri are bioluminescent marine bacteria that can be isolated from their symbiotic animal partners or from ocean water. A V. fischeri population increases exponentially inside the light organ of the Hawaiian bobtail squid (Euprymna scolopes) while the host is quiescent during the day. This bacterial light organ population reaches stationary phase and then remains high during the night...

Abstract Star-forming, H ? -emitting clumps are found embedded in the gaseous tails of galaxies undergoing intense ram pressure stripping galaxy clusters, so-called jellyfish galaxies. These offer a unique opportunity to study star formation under extreme conditions, absence an underlying disk and within hot intracluster medium. Yet, comprehensive, high-spatial-resolution these systems is missi...

Long-term batch cultures of Escherichia coli grown in nutrient-rich medium accumulate mutations that provide a growth advantage in the stationary phase (GASP). We have examined the survivors of prolonged stationary phase to identify loci involved in conferring a growth advantage and show that a mutation in the hns gene causing reduced activity of the global regulator H-NS confers a GASP phenoty...