The gastric mucosa is continuously exposed to many noxious factors and substances. How the gastric mucosa maintains structural integrity and resists auto-digestion by substances such as acid and pepsin puzzled clinicians and investigators for more than 200 years. The gastric epithelium must also resist damage from extrinsic agents, including Helicobacter pylori (H. pylori) and noxious ingestion...

INTRODUCTION: Ulcer is a common disorder of the gastrointestinal system, which causes much discomfort to patients, disrupting their daily routines and causes mental agony. Peptic ulcer is defined as a break off in the continuity of the mucosa of stomach or duodenum as a consequence of some medications like nonsteroidal anti-inflammatory drugs (NSAIDS), gastric acids and pepsin finally causes le...

Cigarette smoking has been linked with duodenal ulcer disease although the mechanism of this association is unclear. This study assessed basal gastric secretory response to acute smoking of smokers with an active duodenal ulcer; in addition the possible effects of chronic smoking on gastric secretory capacity, as expressed by pentagastrin stimulated gastric acid secretion and fasting serum peps...

The isolation of group specific B substance from human stomach juice is described. The substance is carbohydrate-like in nature and is as potent as the carbohydrate-like substance group A isolated from commercial pepsin and peptone respectively.

The commonly accepted model for gastric emptying suggests that the 'antral mill' is responsible for the triturition and subsequent emptying of solid food from the stomach. Little is known about the contribution to solid emptying made by other digestive mechanisms such as acid-pepsin secretion. We have investigated the effect of inhibiting gastic secretion on the rate at which a solid test meal ...

Kinoshita, Mine, Eisuke Kume, Shigeki Igarashi, Nobuko Saito, and Hiroshi Narita. Role of salivary mucin in the protection of rat esophageal mucosa from acid and pepsin-induced injury. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G796–G800, 1999.—The mucosal defensive mechanisms of the esophagus against acid and pepsin remain to be elucidated. In the present study, we investigated the...

1. A method is described for the preparation of pepsinogen from swine gastric mucosae which consists of extraction and fractional precipitation with ammonium sulfate solutions followed by two precipitations with a copper hydroxide reagent under particular conditions. Crystallization as very thin needles takes place at 10 degrees C., pH 5.0 and from 0.4 saturated ammonium sulfate solution contai...

OBJECTIVE To examine whether in vitro exposure of mouse middle ear epithelial cells (mMEECs) to conditions that mimic physiologic reflux upregulates Muc5b gene expression and alters cell viability. DESIGN In vitro mMEEC model. SETTING Center for Genetic Medicine Research, Children's National Medical Center, Washington, DC. PARTICIPANTS Cells from the immortalized mMEEC line. MAIN OUTCOM...