Amongst white population of developed countries, the prevalence of oesophageal adenocarcinoma has dramatically increased during the last four decades. During this period, the increased damage to the oesophageal mucosa with gastroesophageal reflux could result from increased acid output (due to absence of Helicobacter pylori in the gastric mucosa with excellent sanitation) and/or increased frequ...

In Western populations, cancers originating in the esophagus, gastroesophageal junction (gej), and stomach represent a major health problem and are considered highly lethal diseases, with an overall 5-year mortality rate that ranges from 17% to 27%1. Unfortunately, most of these patients present with latestage disease, when curative therapy is not possible1. Although surgical resection remains ...

The distinction between breast and müllerian carcinomas from each other and from tumors with a similar cytokeratin profile can be difficult. We tested the usefulness of 2 new markers, NY-BR-1 and PAX8, by staining a variety of breast and gynecologic carcinomas, along with tumors of pancreas, bile ducts, stomach, and gastroesophageal junction. NY-BR-1 expression (ie, H score >10) was seen in 58....

Gastroesophageal reflux disease is a widespread chronic in which stomach or duodenal contents rise up into the esophagus. Esophageal spasm and achalasia cardia are poorly studied disorders associated with impaired neuromuscular impulse transmission motor discoordination of esophagus, manifested by chest pain dysphagia. The article presents clinical case young patient gastroesophageal history at...

In the last decades, the incidence of gastric cancer has decreased in Western countries, whilst that of gastroesophageal junction has progressively increased [1]. Th is has triggered a lot of studies aiming to unveil environmental causes potentially involved in these trends [2]. Th e reduction in Helicobacter pylori (H. pylori) infection rate in the general population, mainly due to improvement...

Background: HER2 serves as an important therapeutic target in gastroesophageal cancer. Differences in HER2 gene signal distribution patterns can be observed at the tissue level, but how it influences the HER2 amplification status has not been studied so far. Here, we investigated the link between HER2 amplification and the different types of gene signal distribution. Methods: Tumor samples from...

Gastroesophageal reflux disease (GERD), or its variation known as laryngopharyngeal reflux (LPR), has been recognized as a potential cause of several laryngeal disorders. Patients with laryngeal cancer have lifestyle risk factors, especially tobacco and alcohol consumption, that play an etiological role in the development of their cancer but also places them at risk for reflux. The question the...

Gastric (including gastroesophageal junction) cancer is the third leading cause of cancer-related death in the world. In China, an estimated 420,000 patients were diagnosed with gastric cancer in 2011, ranking this malignancy the second most prevalent cancer type and resulting in near 300,000 deaths. The treatment landscape of gastric cancer has evolved in recent years. Although systemic chemot...

background the relationship between gastroesophageal reflux (gerd) and airway diseases is still a matter of debate. oscillometry is an objective, independent tool for the evaluation of airway resistance. the main purpose of this study is to comparespirometry and oscillometry results before and after treatment by a proton pump inhibitor (ppi) in a group of gerd patients who have no respiratory s...