We report 2 cases of enteric muco-submucosal elongated polyps (EMSEPs) that presented with gastrointestinal bleeding. The 2 patients are siblings. They both had a history of percutaneous coronary intervention for coronary artery disease and were on dual antiplatelet therapy. They underwent endoscopic resection of the polyps, which displayed identical endoscopic and histological features compati...

Stone and his co-workers * have reported recently on certain unusual pharmacological properties of mecamylamine (3-methylaminoisocamphane) hydrochloride. This compound, a secondary amine, produces a marked and prolonged degree of blood pressure reduction and ganglionic blockade in animals. Blecamylamine also is well absorbed from the gastrointestinal tract, the L. D.so being approximately the s...

Gastrointestinal motility is an integrated process including myoelectrical and contractile activity, tone, compliance and transit. The techniques for the assessment of gastrointestinal motility are multiple and all have their advantages and disadvantages. In the case of suspected abnormal upper gut transit, gastric and small bowel transit scintigraphy followed by small intestinal (antroduodenoj...

Since their introduction into clinical medicine 20 years ago, the glucocorticoids have become therapeutic agents of major importance. They have become associated with numerous clinical consequences involving every system of the body', including the gastrointestinal tract2'3. It now seems pertinent and valuable to review critically the clinically relevant consequences of glucocorticoid therapy f...

Gut microbiota is a compilation of microorganisms dwelling in the entire mammalian gastrointestinal tract. They display a symbiotic relationship with the host contributing to its intestinal health and disease. Even a slight fluctuation in this equipoise may be deleterious to the host, leading to many pathological conditions like Clostridium difficile infection or inflammatory bowel disease (IBD...

The intestinal microbiota plays an important role in the development of post-natal gastrointestinal functions of the host. Recent advances in our capability to identify microbes and their function offer exciting opportunities to evaluate the complex cross talk between microbiota, intestinal barrier, immune system and the gut-brain axis. This review summarizes these interactions in the early col...

Antimicrobial agents occasionally cause certain adverse effects, such as diarrhea and loose stool, by altering the composition of the intestinal flora. Antibiotic-resistant lactic acid bacteria are used to prevent these adverse effects. Although these bacteria are not resistant to several recently introduced antimicrobial agents, bacterial preparations are still sometimes prescribed concomitant...

The role of 5-HT agents in the modulation of lower gastrointestinal function is discussed. Selective serotonin reuptake inhibitors are of potential benefit in functional gastrointestinal diseases although formal evidence is lacking. Novel pharmacological approaches include 5-HT3 antagonists and 5-HT4 agonists. These pharmacological classes have shown beneficial effects on a global efficacy end ...

Since their introduction into clinical medicine 20 years ago, the glucocorticoids have become therapeutic agents of major importance. They have become associated with numerous clinical consequences involving every system of the body', including the gastrointestinal tract2'3. It now seems pertinent and valuable to review critically the clinically relevant consequences of glucocorticoid therapy f...

Since their introduction into clinical medicine 20 years ago, the glucocorticoids have become therapeutic agents of major importance. They have become associated with numerous clinical consequences involving every system of the body', including the gastrointestinal tract2'3. It now seems pertinent and valuable to review critically the clinically relevant consequences of glucocorticoid therapy f...