BACKGROUND Compared to children, adult patients with minimal change disease (MCD) tend to have a slower response to steroids, but little is known about the factors influencing the steroid responsiveness in these patients. In this study, we investigated the difference in the expression of the glomerular glucocorticoid receptor (GCR) according to steroid responsiveness in 28 adult-onset MCD patie...

Mustafa, Shamimunisa B., Robert J. DiGeronimo, Jean A. Petershack, Joseph L. Alcorn, and Steven R. Seidner. Postnatal glucocorticoids induce -ENaC formation and regulate glucocorticoid receptors in the preterm rabbit lung. Am J Physiol Lung Cell Mol Physiol 286: L73–L80, 2004. First published August 29, 2003; 10.1152/ajplung.00342.2002.—At birth, lung fluid clearance is coupled to Na transport ...

BACKGROUND Urinary excreton of low molecular weight proteins such as beta2-microglobulin and retinol binding protein (RBP), and enzymes such as N-acetyl-beta-D-glucosaminidase (NAG), may be useful as indicators of renal tubular dysfunction in diabetes mellitus. OBJECTIVE To describe the profile of urinary protein and enzyme excretion in 240 Chinese patients with type 2 diabetes mellitus in Si...

In the course of screening for the anti-Parkinsonian drugs from a library of traditional herbal medicines, we found that the extracts of choi-joki-to and daio-kanzo-to protected cells from MPP+-induced cell death. Because choi-joki-to and daio-kanzo-to commonly contain the genus Glycyrrhiza, we isolated licopyranocoumarin (LPC) and glycyrurol (GCR) as potent neuroprotective principals from Glyc...

Abstract Lightlike hypersurfaces in semi-Riemannian manifolds admitting concircular vector fields are investigated. We prove that such generally products of lightlike curves and warped product manifolds. In special cases, we show these totally geodesic or screen provided belong to their normal transversal bundles. A number examples furnished, where possible, illustrate the main concepts.

In this paper, we study the two-player generalized cops and robbers (GCR) games introduced by Bonato MacGillivray. Our main goals are to provide: (a) a game-theoretic formulation of GCR (b) self-contained proof that has value an optimal strategy profile. To achieve our goals, first formulate (and CR as special case) zero-sum stochastic game. Then Vertex Labeling (VL) algorithm prove it computes...

The oriented angles between lightlike vectors cannot be defined properly compared to the timelike in Minkowski spacetime. Therefore, we use pseudo-angles any non-lightlike or develop theory of surfaces having constant angle with a fixed nonlightlike direction. We investigate some geometric properties on these such as being tangent developable. Besides, construct ruled by means null helices. giv...

Background Deficiency of the lysosomal glucocerebrosidase (GCR) enzyme results in Gaucher disease, the most common inherited storage disorder [1]. Current treatment consists of enzyme replacement therapy by administration of exogenous GCR. Although effective, it is exceptionally expensive [2]. In Brazil, the public healthcare system provides the drug free of charge for all Gaucher’s patients, w...

If a graph embeds in a surface with k crosscaps, does it always have an embedding in the same surface in which every edge passes through each crosscap at most once? This well-known open problem can be restated using crossing numbers: the degenerate crossing number, dcr(G), of G equals the smallest number k so that G has an embedding in a surface with k crosscaps in which every edge passes throu...

Impaired activity of the lysosomal enzyme glucocerebrosidase (GCR) results in the inherited metabolic disorder known as Gaucher disease. Current treatment consists of enzyme replacement therapy by administration of exogenous GCR. Although effective, it is exceptionally expensive, and patients worldwide have a limited access to this medicine. In Brazil, the public healthcare system provides the ...