In this work a formalism named Differential Hybrid Petri Nets to model and simulate hybrid systems is presented. It is based on the main elements of the semantics of the hybrid automaton and the modeling power of Petri nets. Considering that Wireless Sensor Networks are hybrid systems, this formalism is applied to model a Dynamic Power Management technique based on battery Capacity (GDC). There...

Ethylene oxide (EO) is industrially produced by epoxidation of ethylene on Ag-based heterogeneous catalysts. Electrophilic oxygen species are assumed to be active key in the EO production. This study explores possibility electrochemically these a solid electrochemical cell. Two series Ag based cermet electrodes were prepared either with Yttria Stabilized Zirconia (YSZ), pure ionic conductor, or...

Victoria blight of oats is caused by the fungus Cochliobolus victoriae. This fungus is pathogenic due to its ability to produce the host-selective toxin victorin. We previously identified a 100-kD protein that binds victorin in vivo only in susceptible genotypes and a 15-kD protein that binds victorin in vivo in both susceptible and resistant genotypes. Recently, we determined that the oat 100-...

BACKGROUND AND PURPOSE Guglielmi detachable coils (GDC) used in the treatment of intracranial aneurysms do not always completely occlude the aneurysm. Thus, after an acute subarachnoid hemorrhage (SAH), there is a theoretical risk of rebleeding from coiled aneurysms, especially when blood pressure is elevated. The aim of this study is to determine whether use of hemodynamic augmentation (HA) to...

Saccharomyces cerevisiae can grow on glycine as sole nitrogen source and can convert glycine to serine via the reaction catalyzed by the glycine decarboxylase multienzyme complex (GDC). Yeast strains with mutations in the single gene for lipoamide dehydrogenase (lpd1) lack GDC activity, as well as the other three 2-oxoacid dehydrogenases dependent on this enzyme. The LPD1 gene product is also r...

A core-shell anode consisting of nickel-gadolinium-doped-ceria (Ni-GDC) nanocubes was directly fabricated by a chemical process in a solution containing a nickel source and GDC nanocubes covered with highly reactive {001} facets. The cermet anode effectively generated a Ni metal framework even at 500 °C with the growth of the Ni spheres. Anode fabrication at such a low temperature without any s...

Lung cancer is a malignant disease with poor outcome, which has led to a search for new therapeutics. The PI3K/Akt/mTOR and Ras/raf/Erk pathways are key regulators of tumor growth and survival. In the present study, their roles were evaluated by MTT assay, flow cytometry and Western blotting in lung cancer cells. We found that a high efficacy of antitumor activity was shown with GDC-0941 treatm...

We compared the structural, biochemical, and physiological characteristics involved in photorespiration of intergeneric hybrids differing in genome constitution (DtDtR, DtDtRR, and DtRR) between the C3-C4 intermediate species Diplotaxis tenuifolia (DtDt) and the C3 species radish (Raphanus sativus; RR). The bundle sheath (BS) cells in D. tenuifolia included many centripetally located chloroplas...

Viticultural practices influence both grape and wine quality. The influence of training systems on volatile composition was investigated for Albariño wine from Rías Baixas AOC in Northwest Spain. The odoriferous contribution of the compounds to the wine aroma was also studied. Volatile compounds belonging to ten groups (alcohols, C₆-compounds, ethyl esters, acetates, terpenols, C13-norisoprenoi...

BACKGROUND Mutations in hedgehog pathway genes, primarily genes encoding patched homologue 1 (PTCH1) and smoothened homologue (SMO), occur in basal-cell carcinoma. In a phase 1 clinical trial, we assessed the safety and pharmacokinetics of GDC-0449, a small-molecule inhibitor of SMO, and responses of metastatic or locally advanced basal-cell carcinoma to the drug. METHODS We selected 33 patie...