OBJECTIVE Combined hyperlipidemia is a common disorder, characterized by a highly atherogenic lipoprotein profile and a substantially increased risk of coronary heart disease. The purpose of this study was to establish whether variations of apolipoprotein A5 (APOA5), a newly discovered gene of lipid metabolism located 30 kbp downstream of the APOA1/C3/A4 gene cluster, contributes to the transmi...

This contribution endeavored to investigate the genetic structure and gene flow of flood mosquito, Aedes vexans (Meigen, 1830). Using partial sequences mitochondrial COI gene, available from BOLD Systems GenBank, Haplotypic (Hd) nucleotide (π) diversity, structuring A. at global, continental, country levels were calculated. In total, 1,184 obtained, distributed among America (88.60%; represente...

The upper reaches of the Yangtze River (upper YR) are a biological zone with extremely rich fish diversity, especially endemic fish. However, long-term human interference, such as environmental pollution and cascade hydropower construction, has significantly changed habitat many is threatening number genetic diversity populations. Jinshaia sinensis typical small but rare that found in YR, its s...

Introduction: Dynamic proteolysis, through the ubiquitin-proteasome system, has an important role in DNA transcription and cell cycle, is considered to modulate stress response synaptic plasticity. We investigated whether genetic variants ubiquitin carboxyl-terminal hydrolase 46 ( USP46 ) would be associated with post-traumatic disorder (PTSD) people exposure combat trauma using a case-control ...

The population genetic structure of Simulium tani was inferred from mitochondria-encoded sequences of cytochrome c oxidase subunits I (COI) and II (COII) along an elevational gradient in Cameron Highlands, Malaysia. A statistical parsimony network of 71 individuals revealed 71 haplotypes in the COI gene and 43 haplotypes in the COII gene; the concatenated sequences of the COI and COII genes rev...

We have identified three unrelated individuals and three members of a family with the non-deletion form of Agamma-hereditary persistence of fetal hemoglobin (HPFH). Molecular analysis showed that each individual is a heterozygote for a previously described -195 Agamma (C-->G) mutation. The beta-globin gene cluster was studied using the polymerase chain reaction and related techniques. Haplotypi...

Abstract The cloning of agriculturally important genes is often complicated by haplotype variation across crop cultivars. Access to pan-genome information greatly facilitates the assessment structural variations and rapid candidate gene identification. Here, we identified red glume 1 ( Rg-B1 ) using association genetics analyses in ten reference grade wheat genomes. Glume color an trait charact...

Beckwith-Wiedemann syndrome (BWS) is a fetal overgrowth disorder involving the deregulation of a number of genes, including IGF2 and CDKN1C, in the imprinted gene cluster on chromosome 11p15.5. In sporadic BWS cases the majority of patients have epimutations in this region. Loss of imprinting of the IGF2 gene is frequently observed in BWS, as is reduced CDKN1C expression related to loss of mate...