A rapid genetic algorithm based on chaos mechanism is presented in this paper. We introduced the chaos mechanism into the genetic algorithm to remedy the defect of premature convergence in the genetic algorithm, then continuously compressed the searching intervals of the optimization variable for increasing convergence speed. Experiments indicate that this method is a rapid and effective evolut...

Case control studies have reported associations between specific HLA class II antigens and idiopathic dilated cardiomyopathy (DCM), suggesting that genetically regulated immune response factors may be involved in the pathogenesis of this disease. In this study, families with DCM were used to test the hypothesis that a heritable gene defect in the HLA region is the primary genetic determinant fo...

The function of calcium as a signaling molecule is conserved in eukaryotes from fungi to humans. Previous studies have identified the calcium-activated phosphatase calcineurin as a critical factor in governing growth of the human pathogenic fungus Cryptococcus neoformans at mammalian body temperature. Here, we employed insertional mutagenesis to identify new genes required for growth at 37 degr...

Yeast SRO7 was identified as a multicopy suppressor of a defect in Rho3p, a small GTPase that maintains cell polarity. Sro7p and Sro77p, a homologue of Sro7p, possess domains homologous to the protein that are encoded by the Drosophila tumor suppressor gene lethal (2) giant larvae [l(2)gl]. sro7Delta sro77Delta mutants showed a partial defect of organization of the polarized actin cytoskeleton ...

BACKGROUND The purpose of this study was to determine whether the National Health Interview Survey is a useful source to identify informative families for genetic studies of birth defects. METHODS The 1994/1995 National Health Interview Survey (NHIS) was used to identify households where individuals with two or more birth defects reside. Four groups of households were identified: 1) single no...

Hearing Loss (HL) represents high genetic heterogeneity with an incidence of almost 1 out of 500 newborns in most populations. Approximately half of the cases have a genetic basis that most of them are autosomal recessive non-syndromic (ARNSHL) with DFNB1-related defect in many worldwide populations. Given the heterogeneity of the trait together with the unique infrastructure of Iranian populat...

As a result of the study, new knowledge was obtained for first time about effect FXI locus polymorphism on quality reproduction in dairy cattle, degree influence frequency development pathologies reproductive organs, their clinical manifestation individuals - carriers anomaly and healthy animals established. The embryonic postembryonic mortality, condition safety newborn calves comparison with ...

Cranial meningocoele is a congenital defect in which the fluid-filled meninges alone protrude through a defect in the cranium (Leipold and Davis, 1993) and may be caused by genetic or environmental factors or a combination of both. Surgical correction of this defect in five calves has so far been reported in veterinary literature (Kohli and Naddaf, 1998). A similar condition was reported in a b...

Several sleep disorders have a genetic basis. These conditions include the narcoleptic syndrome, sleep walking, periodic movements in sleep, circadian delay syndromes and familial insomnia. These disorders illustrate different control mechanisms involved in sleep and wakefulness, including those determining the prevalence and timing of NREM and REM activity, somatomotor inhibition and excitatio...

An 11-year-old neutropenic female child with acute lymphoblastic leukemia (ALL) developed a large right frontal mass a month following the induction of chemotherapy. A well encapsulated mass on surgical excision turned out to be aspergilloma with metastatic infiltration in frontal lobe. A genetic defect in form of microsatellite instability was also demonstrated in frontal mass. A possibility o...