نتایج جستجو برای: genetic modifiers

تعداد نتایج: 620378  

2001
Peter T. Anderson

The livestock industries utilize numerous means to alter the performance of meat animals and composition of their resulting carcasses. Inclusion of metabolic modifiers in production systems reflects a continuation of processes that began decades ago with genetic selection and progress in understanding of nutrition, health, and management. Any drug or management practice that affects efficiency ...

Journal: :Cell stem cell 2017
Mingxia Gu Ning-Yi Shao Silin Sa Dan Li Vittavat Termglinchan Mohamed Ameen Ioannis Karakikes Gustavo Sosa Fabian Grubert Jaecheol Lee Aiqin Cao Shalina Taylor Yu Ma Zhixin Zhao James Chappell Rizwan Hamid Eric D Austin Joseph D Gold Joseph C Wu Michael P Snyder Marlene Rabinovitch

In familial pulmonary arterial hypertension (FPAH), the autosomal dominant disease-causing BMPR2 mutation is only 20% penetrant, suggesting that genetic variation provides modifiers that alleviate the disease. Here, we used comparison of induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) from three families with unaffected mutation carriers (UMCs), FPAH patients, and gender-matc...

2016
Olof Leimar Sasha R. X. Dall Peter Hammerstein John M. McNamara

There are many situations where relatives interact while at the same time there is genetic polymorphism in traits influencing survival and reproduction. Examples include cheater-cooperator polymorphism and polymorphic microbial pathogens. Environmental heterogeneity, favoring different traits in nearby habitats, with dispersal between them, is one general reason to expect polymorphism. Currentl...

Journal: :American Journal of Physiology-Heart and Circulatory Physiology 2019

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