Vitamin C (VC) is a potent antioxidant and plays an essential role in collagen synthesis. As we previously reported, senescence marker protein-30 (SMP30) knockout (KO) mice cannot synthesize VC due to the genetic disruption of gluconolactonase (i.e., SMP30). Here, we utilized SMP30 KO mice deprived of VC and found that VC depletion caused pulmonary emphysema due to oxidative stress and a decrea...

A novel concept in available bit rate (ABR) service model as defined by the ATM Forum is the minimum cell rate (MCR) bandwidth guarantee for each connection. In this paper, we present a network bandwidth allocation policy to support each ABR connection’s MCR requirement, as well as its peak cell rate (PCR) constraint. Furthermore, we develop two explicit-rate (ER) based ABR algorithms consisten...

Calcium silicate (CaSiO3, CS) ceramic composites reinforced with graphene nanoplatelets (GNP) were prepared using hot isostatic pressing (HIP) at 1150°C. Quantitative microstructural analysis suggests that GNP play a role in grain size and is responsible for the improved densification. Raman spectroscopy and scanning electron microscopy showed that GNP survived the harsh processing conditions o...

Nanoscience and Nanotechnology have found their way in the fields of pharmacology and medicine. The conjugation of drug to nanoparticles combines the properties of both. In this study, gold nanoparticle (GNP) was conjugated with NKCT1, a cytotoxic protein toxin from Indian cobra venom for evaluation of anti-arthritic activity and toxicity in experimental animal models. GNP conjugated NKCT1 (GNP...

Vascular calcification (VC) is often associated with cardiovascular and metabolic diseases. However, the molecular mechanisms linking VC to these diseases have yet to be elucidated. Here we report that MDM2-induced ubiquitination of histone deacetylase 1 (HDAC1) mediates VC. Loss of HDAC1 activity via either chemical inhibitor or genetic ablation enhances VC. HDAC1 protein, but not mRNA, is red...

The versatility of faba bean Vicia grain as valuable protein feed is hampered by its relatively high level the compounds vicine and convicine (VC), which are antinutritive factors in poultry other non-ruminants. objective this study was to fine-map major locus for VC and, based on this, develop a novel low-VC winter bean. Bi-parental F2-families isogenic lines three different genetic background...

Asynchronous quasi-delay-insensitive (QDI) NoCs have several advantages over their clocked counterparts. Virtual channel (VC) is the most utilized flow control method in asynchronous routers but spatial division multiplexing (SDM) achieves better throughput performance for best effort traffic than VC. A novel asynchronous SDM router architecture is presented. Area and latency models are provide...

Development of medical domain application has been one of the most active research areas. Neural Networks are one of many data mining analytical tools that can be utilized to make predictions for medical data. Model selection for a neural network includes various factors such as selection of the optimal number of hidden nodes, selection of the relevant input variables and selection of optimal c...

This paper presents a neural framework for dealing with the problem of disparity matching in stereo vision. Two different types of neural networks are used in this framework: one is called the vitality conservation (VC) network for learning clustering, and the other is the back-propagation (BP) network for learning disparity matching. The VC network utilizes a vitality conservation principle to...

Graphene nanoplatelets (GNPs) are added as reinforcement to ultrahigh molecular weight polyethylene (UHMWPE) with an intended application for orthopedic implants. Electrostatic spraying is established as a potential fabrication method for synthesizing large-scale UHMWPE-GNP composite films. At a low concentration of 0.1 wt % GNP, the composite film shows highest improvement in fracture toughnes...