نتایج جستجو برای: genetic predisposition to disease
تعداد نتایج: 11159105 فیلتر نتایج به سال:
Hypertension is a major public health problem, and yet, the molecular mechanisms underlying hypertension are poorly understood in the majority of patients. A complex disorder, both environmental and genetic factors predispose individuals to hypertension. Whereas we know much about environmental factors, such as salt intake and exercise, that affect blood pressure, we know less about genetic fac...
Children and adolescents are subject to several periodontal diseases. Although there is a much lower prevalence of destructive periodontal diseases in children than in adults, children can develop severe forms of periodontitis. In some cases, this destructive disease is a manifestation of a known underlying systemic disease. In other young patients, the underlying cause for increased susceptibi...
Limber tail is a condition that typically affects larger working breeds causing tail limpness and pain, resolving without veterinary intervention. It is poorly understood and the disease burden has not been well characterised. Data collected from owners of the Dogslife cohort of Labrador Retrievers have been used to describe incidents and a case-control study was undertaken to elucidate risk fa...
Discrimination is a very real facet of Australian Aboriginal and Torres Strait Islander (ATSI) life. Paradies has detailed the strong links between racism and chronic stress and the influence this may have on general health, confounding the pre-supposed notion that ATSI populations are more genetically predisposed to chronic diseases. For example a genetic predisposition promoting central adipo...
BACKGROUND AND PURPOSE The prediction of genetic predispositions to ischemic stroke (IS) may allow the identification of individuals at elevated risk and thereby prevent IS in clinical practice. Previously developed weighted multilocus genetic risk scores showed limited predictive ability for IS. Here, we investigated the predictive ability of a newer method, polygenic risk score (polyGRS), bas...
Endometriosis is a common, chronic inflammatory disease defined by the presence of extrauterine endometrial tissue. The aetiology of endometriosis is complex and multifactorial, where several not fully confirmed theories describe its pathogenesis. This review examines existing theories on the initiation and propagation of different types of endometriotic lesions, as well as critically appraises...
Candidate gene and genome-wide association studies have led to the discovery of nine loci involved in Mendelian forms of obesity and 58 loci contributing to polygenic obesity. These loci explain a small fraction of the heritability for obesity and many genes remain to be discovered. However, efforts in obesity gene identification greatly modified our understanding of this disorder. In this revi...
Thyroid dysfunction is a common condition mainly affecting women, with a male to female ratio of around 1:10. An organ-specific autoimmune response is the underlying cause in the majority and susceptibility to thyroid autoimmunity is believed to be influenced by an interaction between genetic predisposition and environmental factors, in addition to endogenous factors such as age and sex (Vander...
It is not possible to understand the etiology of hypertension without considering the role of inheritance. Epidemiological evidence indicates that the development of high blood pressure in the population at large depends on the interaction of different types of genes and several environmental influences. The sources of genetic variation in blood pressure distribution are polygenes, polymorphic ...
The aim of this paper is to review the available evidence on what, if any, aspects of autonomic nervous system (ANS) functioning might be related to a genetic predisposition for schizophrenia. The review will necessarily attempt to determine those ANS characteristics that distinguish individuals who are more vulnerable to schizophrenia on a statistical basis than the general population and thos...
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