The requirement of varying doses of warfarin for different individuals can be explained by environmental and genetic factors. We evaluated the frequency of vitamin K epoxide reductase complex subunit 1 (VKORC1) and cytochrome P450 2C9 (CYP2C9) variants together with patientdemographic characteristics and investigated their association with warfarin dose requirement with the ob...

NUDT15 genetic variants and 6-mercaptopurine intolerance in pediatric acute lymphoblastic leukemia: an updated review

Recent large-scale genome-wide association studies (GWAS) have identified a number of genetic variants associated with breast cancer which showed great potential for clinical translation, especially in breast cancer diagnosis via mammograms. However, the amount of interaction between these genetic variants and mammographic features that can be leveraged for personalized diagnosis remains unknow...

One dairy goat herd of mixed breeds was investigated for frequency of genetic variants of alphas1-casein (as1-CN) and relationships between the genetic variants, milk composition, coagulation properties, and breed. Milk composition (percent total solids, solids-non-fats (SNF), fat, protein, casein, and as1-CN), genetic variants of as1-CN, and coagulation properties (coagulation time, coagulatio...

BACKGROUND Advances in high-throughput genomics facilitate the identification of novel genetic susceptibility variants for coronary heart disease (CHD). This may improve CHD risk prediction. The aim of the present simulation study was to investigate to what degree CHD risk can be predicted by testing multiple genetic variants (genetic profiling). METHODS We simulated genetic profiles for a po...

Motivation: Studying the pattern of genetic variants is a primary step in deciphering the basis of biological diversity, identifying key ‘driver variants’ that affect disease states and evolution of a species. Catalogs of genetic variants contain vast numbers of variants and are growing at an exponential rate, but lack an interactive exploratory

ADAMTS13 is a plasma metalloprotease that specifically cleaves the plasma adhesive protein von Willebrand factor (VWF). VWF is a large plasma glycoprotein and mediates platelet adhesion at sites of vascular injury. VWF is synthesized in an ultralarge multimeric form that has a very strong platelet aggregation activity. VWF-induced platelet aggregation depends on its multimeric size, which is co...

tomato as a highly nutritious vegetable crop is widely grown in the world. hybrid seed is preferably used for tomato production. identification of superior hybrid combination is one of the most important steps in the hybrid breeding programs. breeding of high yielding hybrids is expensive and involves testing large numbers of hybrid combinations in multi-environment trials. successful predictio...

BACKGROUND An allele score is a single variable summarizing multiple genetic variants associated with a risk factor. It is calculated as the total number of risk factor-increasing alleles for an individual (unweighted score), or the sum of weights for each allele corresponding to estimated genetic effect sizes (weighted score). An allele score can be used in a Mendelian randomization analysis t...