Sequencing of large fragments of genomic DNA makes it possible to perform comparisons of genomic sequences for identification of protein-coding regions. We have conducted a comparative analysis of homologous genomic sequences of organisms with different evolutionary distances and determined the degree of conservation of the non-coding regions between closely related organisms. In contrast, more...

MOTIVATION Some organisms edit their messenger RNA resulting in differences between the genomic sequence for a gene and the corresponding messenger RNA sequence. This difference complicates experimental and computational attempts to find and study genes in organisms with RNA editing even if the full genomic sequence is known. Nevertheless, knowledge of these editing sites is crucial for underst...

Hymenolepis nana is a common parasite of rodents as well as human intestine. This parasite has beenreported from all over the world, including Iran. The infection rate has been reported up to 40% in someareas. The infection has various clinical manifestations. The parasite could establish severe hyperinfection inpatients with immune deficiency. Regarding the rodents as hosts of the parasite, th...

BACKGROUND With the improvement of genotyping technologies and the exponentially growing number of available markers, case-control genome-wide association studies promise to be a key tool for investigation of complex diseases. However new analytical methods have to be developed to face the problems induced by this data scale-up, such as statistical multiple testing, data quality control and com...

MOTIVATION Although imprinted genes have been ubiquitously observed in nature, statistical methodology still has not been systematically developed for jointly characterizing genomic imprinting effects and patterns. To detect imprinting genes influencing quantitative traits, the least square and maximum likelihood approaches for fitting a single quantitative trait loci (QTL) and Bayesian method ...

Finding new protein-coding genes is one of the most important goals of eukaryotic genome sequencing projects. However, genomic organization of novel eukaryotic genomes is diverse and ab initio gene finding tools tuned up for previously studied species are rarely suitable for efficacious gene hunting in DNA sequences of a new genome. Gene identification methods based on cDNA and expressed sequen...