Liver injury treatments are among the most important of today’s research domains, because with every passing year there is a more acute need for liver transplants. Many of the everyday drugs that people use, and all the toxic influences and unhealthy food lead to some form of liver disorder. That is why today’s attention is drawn to the potentials of a few miracle plants that have the ability t...

We describe a novel pharmacological activity of the gentian root, an ingredient of Chinese medicines. Root extract from Gentiana triflora triggered cell death of human Daudi cells in culture. In addition, daily administration of the extract to mice inhibited growth of implanted solid tumors. Extract treatment of cultured cells resulted in the appearance of shranken, fragmented, or condensed cel...

In plant-based medical systems, bitter tasting plants play a key role in managing dyspepsia. Yet when it comes to defining their mechanism of activity, herbalists and pharmacologists are split between two theories: one involves cephalic elicited vagal responses while the other comprises purely local responses. Recent studies indicate that bitters elicit a range of cephalic responses which alter...

Extracts from the dried roots of gentian plant, Gentiana triflora, exhibit an antiproliferative activity against cultured and implanted tumor cells. However, the underlying mechanism has been unclear. In the present study, we show that the cell death induced by the extract occurs caspase-independently and depends on metabolic status of mitochondrial respiration. We observed that sensitivity to ...

Temperature plays a key role in outdoor industrial cultivation of microalgae. Improving the thermal tolerance of microalgae to both daily and seasonal temperature fluctuations can thus contribute to increase their annual productivity. A long term selection experiment was carried out to increase the thermal niche (temperature range for which the growth is possible) of a neutral lipid overproduci...

, R. Ardito , C. Arnaboldi , D. R. Artusa , F. T. Avignone III , M. Balata , , M. Barucci , J. Beeman , C. Brofferio , C. Bucci , S. Capelli , F. Capozzi , , S. Cebrian , O. Cremonesi , R. J. Creswick , M. Dolinski , A. de Waard , ,F. Ferroni , E. Fiorini , G. Frossati , C. Gargiulo , A. Giuliani , E. Guardincerri , , E. E. Haller , I. G. Irastorza , E. Longo , G. Maier , R. Maruyama , , S. Mor...

1Rheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; 2Rheumatology Department of Lucania, Ospedale San Carlo di Potenza e Ospedale Madonna delle Grazie di Matera, Italy, on behalf of the Italian Society for Rheumatology. Nicolò Pipitone, MD, PhD Ignazio Olivieri, MD Carlo Salvarani, MD Please ad...