OBJECTIVE The aim of this study was to compare responses to single-agent chemotherapies and evaluate the predictive factors of resistance in low risk (LR) gestational trophoblastic disease (GTD). The chemotherapy agents included methotrexate (MTX) and actinomycin D (ACT-D). METHODS We conducted a retrospective study of 126 patients with GTD who were treated between 2000 and 2013. A total of 7...

The advent of the radioimmunoassay of Beta subunit chorionic gonadotropin (BhCG) has eliminated a major problem in following the patient with gestational trophoblastic neoplasia (GTN). Whole hCG cross reacts with luteinizing hormone (hLH) causing difficulties when GTN patient titers fall to levels coincidental with pituitary levels of hLH. The use of the Beta subunit of hCG in radioimmunoassay ...

Objective. Gestational Trophoblastic Disease (GTD) management requires clear guidelines for diagnosis, treatment, and follow-up. Unequal management skills among practitioners, inadequate treatment, irregular surveillance, and drop-out are common in resource-limited settings and can lead to life-threatening complications and morbidities. To address these challenges, we implemented a GTD Manageme...

Choriocarcinoma is an aggressive malignant disease that originates in the trophoblastic cells of the placenta, characterized by early hematogenous spread to the lungs. It belongs to the far spectrum of gestational trophoblastic disease (GTD), a subset of germ cell tumor. It is a hypervascular tumor composed of sheets of malignant cytotrophoblast and syncytiotrophoblast metastasizing hematogenou...

Gestational trophoblastic neoplasia (GTN) describes a heterogeneous group of interrelated lesions that arise from abnormal proliferation of placental trophoblasts. GTN lesions are histologically distinct, malignant lesions that include invasive hydatidiform mole, choriocarcinoma, placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT). GTN tumors are generally highly...

BACKGROUND Klippel-Trenaunay syndrome is a non-heritable venous malformation with bone and soft tissue hypertrophy and cutaneous nevi. CASE CHARACTERISTICS Neonate with Klippel Trenaunay syndrome born to a mother with past history of Gestational trophoblastic neoplasm. OBSERVATION Antenatally, a fetal vascular malformation was identified ultrasonologically at 29 weeks gestation. Acute myelo...

Gestational trophoblastic disease (GTD) is characterized by abnormal proliferation of pregnancy-associated trophoblastic tissue with malignant potential. GTD covers a spectrum of tumors and tumor-like conditions and may occur in a benign form as hydatiform mole or as malignancy in the form of invasive mole or choriocarcinoma. GTD has become a curable malignant disease since the introduction of ...

The reported incidence of gestational trophoblastic disease is 1-2:1000 pregnancies. The disease includes a) hydatidiform mole (partial and complete), b) invasive mole, c) choriocarcinoma and d) placental site trophoblastic tumors. Current management is based on several prognostic risk factors. We describe an interesting case of a 51-year–old woman who presented with abnormal vaginal bleeding a...

The World Health Organisation’s (WHO) classification of gestational trophoblastic disease includes complete, partial, invasive and metastatic hydatidiform mole, exaggerated placental site nodule or plaque and two malignant tumoursplacental site trophoblastic tumour and choriocarcinoma [1]. The incidence of gestational trophoblastic disease (GTD) in Sri Lanka according to a hospital based study ...

Indications and outcomes of hysterectomy in women with gestational trophoblastic neoplasia (GTN) were reviewed at Chiang Mai University Hospital, Chiang Mai, Thailand. From January 1998 through December 2008, 18 women underwent simple transabdominal hysterectomy (TAH). Indications for TAH included suspicious lesions confined to the uterus (5), chemoresistant lesions confined to the uterus (7), ...