نتایج جستجو برای: gleevec

تعداد نتایج: 513  

2015
Roman V. Agafonov Christopher Wilson Dorothee Kern

Sophisticated protein kinase networks, empowering complexity in higher organisms, are also drivers of devastating diseases such as cancer. Accordingly, these enzymes have become major drug targets of the twenty-first century. However, the holy grail of designing specific kinase inhibitors aimed at specific cancers has not been found. Can new approaches in cancer drug design help win the battle ...

2013
Li Yan

A total of 23 new cancer medicines or indication expansions were approved by the U. S. Food and Drug Administration in 2012. Among these, 12 are new molecular entities (NMEs)--new chemical or biological drugs approved for the first time for oncologic use--and 10 of these NMEs are molecular targeted agents. Among the 10 targeted agents, 4 are anti-angiogenesis agents and 2 are Bcr-Abl pathway in...

Journal: :Blood 2009
Lucien Noens Marie-Anne van Lierde Robrecht De Bock Gregor Verhoef Pierre Zachée Zwi Berneman Philippe Martiat Philippe Mineur Koen Van Eygen Karen MacDonald Sabina De Geest Tara Albrecht Ivo Abraham

Imatinib mesylate (imatinib) has been shown to be highly efficacious in the treatment of chronic myeloid leukemia (CML). Continuous and adequate dosing is essential for optimal outcomes and with imatinib treatment possibly being lifelong, patient adherence is critical. The ADAGIO (Adherence Assessment with Glivec: Indicators and Outcomes) study aimed to assess prospectively over a 90-day period...

Journal: :Acta poloniae pharmaceutica 2014
Andrzej Ostrowicz Przemysław L Mikołajczak Marzena Wierzbicka Piotr Boguradzki

The aim of the study was to investigate the bioavailability of a generic product of 100 mg and 400 mg imatinib film-coated tablets (test) as compared to that of a branded product (reference) at the same strength to determine bioequivalence. The secondary objective of the study was to evaluate tolerability of both products. An open-label, randomized, crossover, two-period, single-dose, comparati...

2010
Collin M McClelland George J Harocopos Philip L Custer

Imatinib mesylate (Gleevec((R))) is a well-established pharmacologic treatment for all phases of chronic myeloid leukemia and for advanced gastrointestinal stromal tumors (GISTs). Edema-related side effects are relatively common in imatinib therapy with the periocular skin representing one of the most common sites for localized edema. While the adverse effect of periorbital edema with imatinib ...

Journal: :Cancer research 2004
Robert R Langley Dominic Fan Rachel Z Tsan Robert Rebhun Junqin He Sun-Jin Kim Isaiah J Fidler

The activation of the microvascular endothelial cell platelet-derived growth factor (PDGF) receptor (PDGF-R) by PDGF has been implicated in neoplastic angiogenesis. Here, we established cultures of murine bone microvascular endothelial cells and examined their response to stimulation with PDGF BB ligand and to blockade of PDGF-R signaling with the tyrosine kinase inhibitor STI571 (Gleevec). The...

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