In an earlier communication (1) attention was called to the marked depressions of albumin: globulin ratios that frequently occur in the course of louse-borne typhus fever. Serum globulin concentrations in a number of cases were found to be higher than 5 grams per 100 ml. Because of the consistent rise in serum globulins in this disease, possibly a feature of the immune response, it was of inter...

An attempt is made to describe the nature of the chemical interactions participating in blood clotting. In the laboratory, thrombin can be derived directly from prothrombin without the physiologic activators calcium, thromboplastin, Ac-globulin, and platelet derivatives. The newly recognized clotting factor, Ac-globulin, is essential for normal physiologic hemostasis. Plasma Ac-globulin concent...

The long-standing observations that respiratory secretions contain virus-neutralizing substances (1-3) have recently been extended by the demonstration that antibody activity associated with the yA-globulin in nasal secretion may protect against respiratory virus infection (4). Since protection was most clearly seen in individuals with relatively high titers of nasal antibody, and since yA-glob...

An attempt is made to describe the nature of the chemical interactions participating in blood clotting. In the laboratory, thrombin can be derived directly from prothrombin without the physiologic activators calcium, thromboplastin, Ac-globulin, and platelet derivatives. The newly recognized clotting factor, Ac-globulin, is essential for normal physiologic hemostasis. Plasma Ac-globulin concent...

Serum protein concentrations provide insight into the nutritional and immune status of organisms. It has been suggested that some marine turtles are capital breeders that fast during the nesting season. In this study, we documented serum proteins in neophyte and remigrant nesting leatherback sea turtles (Dermochelys coriacea). This allowed us to establish trends across the nesting season to det...

Hypophysectomy is known to cause complete suppression of the hepatic synthesis az,-globulin. The effect of hypophysectomy on the synthesis of azu-globulin can be reversed by multiple hormone treatment. The role of pituitary growth hormone in the multihormonal regulation of aZ,-globulin in rat liver was examined in the hypophysectomized male rats with and without growth hormone supplementation. ...

1. We have correlated measurements of colloid osmotic pressure with protein concentrations and albumin/globulin ratios. Plasma from normal rats of different genetic strains was used. 2. The Landis and Pappenheimer equation does not accurately predict colloid osmotic pressure properties of the normal rat plasma used, which had an albumin/globulin ratio of 0.74. Over the range 2-2-12-2 g of prote...

One of us (LWS) bad occasion to treat a young white man with gamma globulin for prophylaxis after exposure to infectious hepatitis. He was given two injections, 10 cc. each, of human Poliomyelitis Immune Globulin, one week apart. It was observed that shortly after the second injection, his severe pustular and indurated acne improved considerably. This observation led to the present study, of wh...

S-sulfonated gamma globulin (GGS), newly developed as a safe drug for intravenous use, was studied for its protective effects against some experimental infections in mice. Gamma globulin showed a good protective activity against infections due to Streptococcus pneumoniae and Escherichia coli and was moderately active against infections due to Staphylococcus aureus and Pseudomonas aeruginosa. In...

1863 liter three years before admission. Instead of providing immediate immune globulin replacement on admission, his clinicians remeasured the serum IgG five days later (130 mg per deciliter), and immune globulin replacement was given seven days after admission. The patient died on the 12th hospital day. There is an extensive body of literature supporting the value of intravenous immune globul...