BACKGROUND To evaluate immunotherapy against canine visceral leishmaniasis, Leishmania major antigen and heat-killed Mycobacterium vaccae (SRL172) were used as stimulators of immune defense mechanisms and the results were compared with standard chemotherapy meglumine antimoniate. METHODS Nineteen mongrel dogs aging 1-3 years old were used in this experiment. Infection was carried out in 15 ou...

Introduction: The aim of this study was to evaluate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in patients with recurrent aphthous stomatitis (RAS).   Materials and Methods: Eighty patients who were diagnosed with RAS between January 2014 and January 2016 were included in this study. Eighty age- and gender-matched healthy subject...

background: an increase in the number of intraepithelial lymphocytes (iel) in the duodenal mucosa is an important criterion for the histological diagnosis of celiac disease (cd). we determined the normal range for intraepithelial lymphocytes (iel) in the second part of duodenum in healthy iranian population. materials and methods: four biopsy samples of the endoscopically normal appearing mucos...

background polyvinyl alcohol (pva) is one of the well-known polymers, which has been used in numerous biomedical applications because of its good biocompatibility. objectives due to problems made by the therapeutics already used for leishmaniasis, the aim of this study was to evaluate the effect of pva containing artemether in treating cutaneous leishmaniasis in balb/c mice. materials and metho...

Objective Characterize the foci of visceral leishmaniasis infection in Neiva with a clinical and epidemiological approach. Materials and Methods Six children consulted medical services with hepatosplenomegaly. They were found to have anemia and leukopenia. The diagnosis was performed by bone marrow (five patients) and spleen (1 patient) aspiration. An active search for cases was carried out in ...

The activity of five (1-5) abietane phenol derivatives against Leishmania infantum and Leishmania braziliensis was studied using promastigotes and axenic and intracellular amastigotes. Infectivity and cytotoxicity tests were performed with J774.2 macrophage cells using Glucantime as a reference drug. The mechanisms of action were analysed by performing metabolite excretion and transmission elec...

BACKGROUND Pentavalent antimonials are the first line drugs for the treatment of leishmaniasis. Unresponsiveness of Leishmania spp. to antimonial drugs is a serious problem in some endemic areas. Investigations on molecular mechanisms involved in drug resistance are essential for monitoring and managing of the disease. Cal-cineurin is an essential protein phosphatase for number of signal transd...

introduction: the aim of this study was to evaluate the neutrophil-to-lymphocyte ratio (nlr), platelet-to-lymphocyte ratio (plr), and mean platelet volume (mpv) in patients with recurrent aphthous stomatitis (ras).   materials and methods: eighty patients who were diagnosed with ras between january 2014 and january 2016 were included in this study. eighty age- and gender-matched healthy subject...

background: sensitive and glucantime (ma) resistance leishmania tropica are referred to those isolates, which are responsive, or non-responsive to one or two full courses of treatment by ma systematically and/or intra-lesionally, respectively. in this study, we evaluated the antileishmanial activity of biogenic selenium nanoparticles (se nps) alone and in combination with ma against sensitive a...