BACKGROUND Beta-glucosidase inhibitors are being extensively studied for use as anti-diabetics, anti-obesity and anti-tumour compounds. So far, these compounds have been reported in large numbers from plants, mushrooms, algae and fungi. There are very few reports of such inhibitors from bacteria in the open literature, particularly marine bacteria; although the best known inhibitor deoxynojirim...

Inhibition of α-glucosidase has been used as a management type 2 diabetes mellitus, where studies are focused on finding more efficacious and safe drugs. Herein, the research aimed to unveil potential phytoconstituents contained in methanol extract Muntingia calabura leaves inhibiting through molecular docking simulation. From systematic search (Scopus), we found 5 eligible articles identified ...

The identification of naturally occurring α-glucosidase inhibitors has been actively pursued with the aim of developing therapeutics for the treatment of type 2 diabetes mellitus. To identify α-glucosidase inhibitors, we screened 40 natural compounds, including flavonoids and phenolics, using the structure-based molecular docking approach. The rank of each compound was determined on the basis o...

Three new compounds; epi-mukulin, (Z)-Δ(1,2) dehydroguggulsterone and Δ(6,7)dehydro-20-hydroxygugglsterone were isolated from the n-hexane-soluble fraction (HSF) of the methanol extract of guggul, the oleogum resin of Commiphora wightii together with six known compounds: diasesartemin, (+)-epi-magnolin, (+)-diayangambin, gugglsterol I, (E)-guggulsterone and (Z)-guggulsterone. Their structures w...

α-Glucosidase inhibition is considered as an effective strategy for the treatment of diabetes mellitus. Currently, three α-glucosidase inhibitors are being used drugs; Acarbose, Voglibose and Miglitol. The side effects these drugs forcing researchers to search new molecules. In this research work, novel 1,2,3-benzotriazin-4(3H)-one sulfonamides were synthesized investigated their activity. 2,4,...

the leopard moth, zeuzera pyrina, is a key and worldwide pest damaging walnut as well as many other fruit trees during the larval stages. larvae were collected from infested twigs of walnut trees. midguts from larvae were removed under a stereomicroscope and their homogenates used as the enzyme source. larval midgut extracts showed an optimum activity at ph 8.0, 6.0 and 6.0 for ?-amylase, ?- an...

BACKGROUND α-glucosidase inhibitors regulate postprandial hyperglycemia (PPHG) by impeding the rate of carbohydrate digestion in the small intestine and thereby hampering the diet associated acute glucose excursion. PPHG is a major risk factor for diabetic vascular complications leading to disabilities and mortality in diabetics. Cinnamomum zeylanicum, a spice, has been used in traditional medi...

This study investigated the hypoglycemic effect of the Padina arborescens extract in STZ-induced diabetic mice. Freeze-dried Padina arborescens were extracted with 80% methanol and concentrated for use in this study. The hypoglycemic effect was determined by inhibitory activities against α-glucosidase and α-amylase as well as the alleviation of postprandial blood glucose level. Padina arboresce...

Inhibition of intestinal alpha glucosidase plays a major role in preventing rise in postprandial glucose level in diabetics. Cymbopogon martinii (CM) (family Poaceae) is used in traditional Indian medicine in treatment of diabetes mellitus. The alpha glucosidase inhibitory action of the plant is studied. The active component was separated using hot water extraction of the whole plant powder, di...

The entrocytes of the small intestine can only absorb monosaccharides such as glucose and fructose from our diet. The intestinal absorption of dietary carbohydrates such as maltose and sucrose is carried out by a group of α-glucosidases. Inhibition of these enzymes can significantly decrease the postprandial increase of blood glucose level after a mixed carbohydrate diet. Therefore, the inhibit...