the isolated perfused rat liver (iprl) model has been used into toxicology study of rat liver. this model provides an opportunity at evaluation of liver function in an isolated setting. studies showed that cd, in a dose-dependent manner, induced toxic effects in iprl models, and these effects were associated with aminotransferase activity and lipid peroxidation. the aim of this study was to inv...

conclusions plasma se and gpx levels were lower in type two diabetic patients with macroalbuminuria and related to the stage of diabetic nephropathy. results plasma se and gpx concentrations were significantly lower in diabetic patients with macroalbuminuria than other study groups (p < 0.001). albuminuria (alb/cr in random urine sample) had a negative correlation with plasma se (r = -0.40, p =...

introduction: amnesia or loss of memory is the cardinal hallmark of alzheimer’s disease (ad), a progressive neurodegenerative disorder associated with ageing process. although, ad had been discovered over a century ago, drugs which could cure or halt the progression of the disease are yet to see the light of the day. however, there has been a growing interest in the use of phytomedicines with m...

Glutathione is an important antioxidant in the lungs but its concentration is low in the airways of patients with cystic fibrosis. Whether this deficit occurs from an early age or how oxidative stress contributes to lowering glutathione is unknown. We measured glutathione, its oxidation products, myeloperoxidase, and biomarkers of hypochlorous acid in bronchoalveolar lavage from children with c...

Substantial evidence suggests that oxidative stress in the lungs can affect the pathological events observed in asthma. We used a guinea pig model of asthma to assess whether the early asthmatic reaction is associated with decreased lung levels of glutathione, and whether a decrease in glutathione is implicated in the increased airway smooth muscle reactivity that is associated with exposure of...

M����� L.P-E., I����� S.V., A������� V.S., K������ E.N. (2004): Effect of atrazine on glutathione levels, glutathione S-transferase and glutathione reductase activities in pea and wheat plants. Plant Protect. Sci., 40: 16–20. Changes were studied in the endogenous level of glutathione (total and oxidised), and in the amount of free thiol groups as caused by the herbicide atrazine on two species...