Four pig hybrids (Pannon, Hungahib-39, Középtiszai and Dalland) were fattened up to 100±2 kg body weight. Feed intake and body weight were measured and daily weight gain was calculated. Malondialdehyde (MDA) and reduced glutathione (GSH) content, and glutathione peroxidase (GPx) activity were measured in liver and kidney. Daily weight gain was significantly lower in Pannon and Hungahib-39 hybri...

We recently found that estrogen deficiency leads to a lowering of thiol antioxidant defenses in rodent bone. Moreover, administration of agents that increase the concentration in bone of glutathione, the main intracellular antioxidant, prevented estrogen-deficiency bone loss, whereas depletion of glutathione by buthionine sulfoximine administration provoked substantial bone loss. To analyze fur...

Selenium (Se) was discovered in 1817, and in mammals its deficiency has been associated with many fatal diseases, such as cancer, HIV, cardiovascular and Keshan-Back [1, 2]. In most selenoproteins discovered so far, Se is present as a selenocysteine residue that plays an important role in the catalytic activities of these enzymes [3]. One of the first selenoproteins to be discovered was Glutath...

Reactive oxygen species (ROS) are mediators of chronic tissue damage and fibrosis. Endogenous antioxidants may increase in response to oxidants and reduce tissue injury. We investigated the antioxidant response of the lungs to the chronic release of ROS, as occurs in the immune-specific granulomatous inflammation of chronic beryllium disease (CBD), and compared it with that in healthy controls ...

Previous in vitro experiments have shown that hyperhomocysteinemia leads to oxidative inactivation of nitric oxide, in part by inhibiting the expression of cellular glutathione peroxidase (GPx-1). To elucidate the role of intracellular redox status on homocysteine-induced endothelial dysfunction and oxidant stress, heterozygous cystathionine -synthase–deficient (CBS ) and wild-type (CBS / ) mic...

Introduction: Antioxidant defense components protect insects by scavenging reactive oxygen species, leading to oxidative stress. We therefore investigated the effect of an organophosphate insecticide, dichlorvos, on superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione S-transferase (GST) and glutathione reductase (GR) as antioxidative biomarkers in silk worm, Bo...

Previous in vitro experiments have shown that hyperhomocysteinemia leads to oxidative inactivation of nitric oxide, in part by inhibiting the expression of cellular glutathione peroxidase (GPx-1). To elucidate the role of intracellular redox status on homocysteine-induced endothelial dysfunction and oxidant stress, heterozygous cystathionine beta-synthase-deficient (CBS(-/+)) and wild-type (CBS...

Garcinia mangostana (GM) pericarp is an herbal medicine in the Thailand National Essential Drug List. GM and its major active constituent α-mangostin (MGS) exhibit several pharmacological properties, including anti-oxidative activity. Ulcerative colitis (UC) consequence of prolonged oxidative stress inflammation large intestine can result in extraintestinal manifestations (EIM) other ...