Inorganic arsenic exposure via drinking water has been associated with cancer and serious injury in various internal organs, as well as with peripheral neuropathy and diverse effects in the nervous system. Alterations in memory and attention processes have been reported in exposed children, whereas adults acutely exposed to high amounts of inorganic arsenic showed impairments in learning, memor...

Isozymes of glutathione reductase (GR) have been purified from red spruce (Picea rubens Sarg.) needles. Two isozymes could be separated by anion-exchange chromatography from both nonhardened or cold-hardened tissue. Based on chromatographic elution profiles, the isozymes were designated GR-1NH and GR-2NH in preparations from nonhardened needles, and GR-1H and GR-2H in preparations from hardened...

Introduction The flavoprotein disulphide oxidoreductases constitute a growing family of homologous dimeric enzymes, with an important and diverse range of functions in vivo. Among its members are dihydrolipoyl dehydrogenase, glutathione reductase, mercuric reductase, thioredoxin reductase, trypanothione reductase and a related enzyme, NADPH peroxidase (for recent reviews of their structures and...

It has been suggested that oxidative stress is a feature of aging. The goal of the present study was to assess the oxidant effects related to aging and the protective role of exogenous melatonin in senescence-accelerated mice (SAMP8). Two groups of SAMP8 mice (males and females) were compared with their respective control groups of SAMR1 mice (senescence-resistant inbred strain) to determine th...

Cyanobacteria ("blue-green algae") are recognized producers of a diverse array of toxic secondary metabolites. Of these, the lipopolysaccharides (LPS), produced by all cyanobacteria, remain to be well investigated. In the current study, we specifically employed the zebrafish (Danio rerio) embryo to investigate the effects of LPS from geographically diverse strains of the widespread cyanobacteri...

BACKGROUND Nigella sativa is an important component of several traditional herbal preparations in various countries. It finds its applications in improving overall health and boosting immunity. The current study evaluated the role of fixed and essential oil of Nigella sativa against potassium bromate induced oxidative stress with special reference to modulation of glutathione redox enzymes and ...

BACKGROUND Hepatitis is a health problem affecting millions of people worldwide and it is the major risk factor for liver cirrhosis. In India, many plants are used to treat hepatitis. But little is known about the effects of (-)-epicatechin a bioactive compound of Phyllanthus niruri (PN) in hepatitis rats. OBJECTIVE The present study was designed to explore the antioxidant property of (-)-epi...

Supplementation has beneficial effects in immune system and can antioxidant enzymes activity increases during the exercise and protects the tissue against the oxidative stress. L-Carnitine is a famous Supplement and helps to protect against the oxidative stress during and after intense or prolonged exercise. The aim of this study was to investigate the effect of L-Carnitine supplementation on t...

Boerhaavia diffusa (Nyctaginaceae) is conventionally used in Indian Ayurvedic system to treat liver diseases. The present study was undertaken to investigate the protective role of ethanol extract of B. diffusa on hepatic antioxidant status and the levels of diagnostic markers in isoproterenol induced hepatitis in rats. The Prior oral administration of B. diffusa extract [150 mg/kg bodyweight/d...

The present study investigates the roles of exogenous proline (Pro, 5 mM) and glycine betaine (GB, 5 mM) in improving salt stress tolerance in salt sensitive (BRRI dhan49) and salt tolerant (BRRI dhan54) rice (Oryza sativa L.) varieties. Salt stresses (150 and 300 mM NaCl for 48 h) significantly reduced leaf relative water (RWC) and chlorophyll (chl) content and increased endogenous Pro and inc...