fascioliasis is a worldwide parasitic disease in human and domestic animals. the causative agents of fascioliasis are fasciola hepatica and fasciola gigantica. in the recent years, fasciola resistance to drugs has been reported in the many of publications. fasciola spp has detoxification system including gst enzyme which may be responsible for its resistance. therefore , the aim of the study wa...

thioredoxins (trxs) are small ubiquitous oxidoreductase proteins with two redox-active cys residues in a conserved active site (wcg/ppc) that regulate numerous target proteins via thiol/disulfide exchanges in the cells of prokaryotes and eukaryotes. the isoforms ostrx23 with a typical active site (wcgpc) and ostrx20 with an atypical active site (wctpc) are two  trx h- type isoforms in rice that ...

objective(s): because of the high total phenolic contents of feijoa sellowiana , its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (mdma) treated mice.   materials and methods: animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of f. sellowiana leaves, intra-peritoneally. after one hour, an acute administration of mdma (20 mg/kg, ip) was inj...

background: the glutathione s-transferase (gst) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. the expression of many of these cancer susceptibility enzymes is genetically polymorphic. an increased frequency of gst-null genotypes has been associated with several malignancies. objective: to investigate the rate of gstt1 and gstm1 null ge...

background: diazinon (dzn) is an organophosphate pesticide that widely used for agricultural pest control all over the world. dzn affects target organs including reproductive system by inhibiting the activity of acetylcholinesterase and inducing oxidative stress. vitamin e (α-tocopherol) is a strong antioxidant which inhibits free radicals, and probably can reduce lipid perxidation effectively ...

background: endometriosis is one of the most common gynecologic disorders. it is a complex trait and both genetic and environmental factors have been implicated in its pathogenesis. there is growing evidence indicating that exposure to environmental contaminants is a risk factor for endometriosis. glutathione-s-transferase m1 (gstm1) is one of the genes involved in detoxification of endogenous ...

Many functions have been ascribed to glutathione, a tripeptide that has been known for almost a century.* Glutathione is found in virtually all mammalian cells, usually in substantial concentrations (0.510 mM). The concentration of glutathione in extracellular fluids such as blood plasma is in the micromolar range. The intracellular concentration of glutathione exceeds by far that of glutathion...

A major objective in the characterization of protein kinase activity is to determine phosphoamino acid identity in substrate proteins. Several fundamentally different phosphoamino acid analysis (PAA) procedures are available to identify phosphorylated amino acids (2,3). Phosphoamino acids can be released from proteins by partial hydrolysis (4) and identified directly by oneor two-dimensional hi...

The antioxidant potential of foods plays a vital role in counteracting oxidative stress and its consequences the body. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) are primary line defence against cellular damage caused by reactive oxygen species (ROS). Glutathione is considered to be most for body because changes during increase risk CVD. dietary capacity supporting...