Due to their well-defined plasmonic properties, gold nanorods (GNRs) can be fabricated with optimal light absorption in the near-infrared region of electromagnetic spectrum, which make them suitable for cancer-related theranostic applications. However, controversial safety profile, as a result surfactant stabilization during synthesis, limits clinical translation. We report facile method improv...

The effect of two gold(I) compounds on stability of lysosomes in vitro was studied. Lysosomes from homogenates of rat kidney cortex were isolated by differential centrifugation. These lysosomes were incubated at 37 degrees C with widely varied concentrations of sodium aurothiomalate and sodium aurothiosulphate for 5, 35, and 65 minutes. Acid phosphatase activities were measured and used as an i...

Gold sodium thiomalate, a drug used widely in the therapy of rheumatoid arthritis, was found to be an activator of latent human polymorphonuclear leukocyte collagenase. The activation was demonstrated by two distinct and independent collagenase assays: by recording with a spectrophotometer at 227 nm the enzyme-induced increase in ultraviolet difference absorbance of native type I collagen conne...

A separation system for gold nanoparticles was developed using monolithic silica capillary columns with 50 µm i.d., which were prepared via in-situ sol-gel processes. Gold nanoparticles with five different average sizes were synthesized via reduction of tetrachloroauric acid (HAuCl(4)) under different synthesis conditions, and were evaluated by UV-visible spectrophotometry, dynamic light scatte...

Gold distribution was studied in the tissues of 7 rheumatoid patients who had died from 0 to 23 years after stopping chrysotherapy (sodium aurothiomalate) and in 23 samples of synovial tissue removed surgically at intervals during chrysotherapy in 5 patients. After the application of a highly specific staining technique, the cellular localization of gold was examined microscopically in various ...

Background The solid and colloidal particles in the range of 1-100 nm are called nanoparticles. Recently, one of the most important metal nanoparticles, with wide usage is gold nanoparticle. Based on the previous studies, gold nanoparticles have spermatotoxic effects and can destroy sperm motility. The aim of present study is the effect of gold nanoparticles on chromatin quality and sperm param...

Gold salts are still the best of all the therapeutic agents used in the treatment of chronic polyarthritis. Complications of varying degrees of severity are encountered in about 50 per cent. of the cases so treated. A mild complication, however, usually causes the patient only slight discomfort, particularly as most often his rheumatic distress simultaneously undergoes rapid alleviation for a s...