The role of the renal vasculature in eliciting renovascular hypertension (RVH) was established in 1934, when Goldblatt et al. [1] in a classical experimental study demonstrated that partial obstruction of the renal artery increased mean arterial blood pressure (BP). The pathophysiology of renal artery stenosis (RAS) is incompletely understood but has been postulated to be related to increased a...

Male Sprague-Dawley rats with unilateral renal artery stenosis and a contralateral untouched kidney develop a malignant hypertension (MH) which is characterized by high blood pressures, sodium and water depletion, and subsequent activation of the renin-angiotensin system. In the present studies we found plasma arginine vasopressin (AVP) concentrations-3-fold higher than those in rats with benig...

Welch WJ, Patel K, Modlinger P, Mendonca M, Kawada N, Dennehy K, Aslam S, Wilcox CS. Roles of vasoconstrictor prostaglandins, COX-1 and -2, and AT1, AT2, and TP receptors in a rat model of early 2K,1C hypertension. Am J Physiol Heart Circ Physiol 293: H2644–H2649, 2007. First published August 31, 2007; doi:10.1152/ajpheart.00748.2007.—Angiotensin (ANG) II activating type 1 receptors (AT1Rs) enh...

Baseline plasma vasopressin concentrations were measured in 48 men (all 50 years old) with decreased plasma renin concentration and untreated, sustained essential hypertension and in 29 healthy normotensive men. Mean hypertensive plasma vasopressin concentration was more than twice as high as the corresponding normotensive level (15.7 +/- 2.2 [SE] vs 7.5 +/- 1.0 pg/ml; p less than 0.001). Plasm...

SINCE the work of Goldblatt, Lynch, Hanzal and Summervillle in 1934 on the production of persistent hypertension in dogs there has been sustained interest in investigating hypertensive patients from the point of view of demonstrating a renal lesion, the surgical treatment of which might lead to permanent relief of hypertension. Many lesions of the kidney have been found -to be associated with h...

The role of the central nervous system, in general, and of the hypothalamus, in particular, in the genesis of various forms of experimental hypertension has been the object of increased investigation. Lesions of the anteroventral area of the third ventricle (AV3V) in rats seem to block the development of various forms of hypertension. In the present experiments, AV3V was kept intact but its con...

The effect of chronic hypertension on acute hypertensive disruption of the blood-brain barrier has been studied in only two models of hypertension, with inconsistent results. The purpose of this study was to reinvestigate whether chronic hypertension has a consistent effect on acute hypertensive disruption of the blood-brain barrier and to determine whether one of the previously studied models ...

SINCE the work of Goldblatt, Lynch, Hanzal and Summervillle in 1934 on the production of persistent hypertension in dogs there has been sustained interest in investigating hypertensive patients from the point of view of demonstrating a renal lesion, the surgical treatment of which might lead to permanent relief of hypertension. Many lesions of the kidney have been found -to be associated with h...

Segerberg established an analogue of the canonical model theorem in modal logic for infinitary modal logic. However, the logics studied by Segerberg and Goldblatt are based on denumerable sets of pairs 〈Γ, α〉 of sets Γ of well-formed formulae and well-formed formulae α. In this paper I show how a generalisation of the infinite cut-rule used by Segerberg and Goldblatt enables the removal of the ...

INTEREST in unilateral renal disease as a possible cause of human hypertension originated with Goldblatt 's classic experiments.' In 1937, Butlerreported the clinieal cure of hypertension following nephrectomy in two cases of unilateral, pyelonephritis with vascular disease in children. In recent years it has been recognized that many cases of human hypertension are on the basis of unilateral r...