Abstract Targeted liposomes are designed to target specific receptors overexpressed on the surfaces of cancer cells. This technique ensures site-specific drug delivery reduce undesirable side effects while enhancing efficiency encapsulated therapeutics. Upon reaching tumor site, these can be triggered release their content in a controlled manner using ultrasound (US). In this study, from pegyla...

based on the evaluation of two human cell lines, hela and chang, abeuploidy and several marker chromosomes were found in both cells. the morphological characteristic of marker chromosomes of chang cells was distinctly different from hela. certain submetacentric marker chromosome was frequently present among 80% of marker chromosomes of chang cells which distinguished this line from hela, which ...

BACKGROUND Catheter-based therapeutic ultrasound thrombolysis was recently shown to be effective and safe. The purpose of this work was to study the safety and efficacy of external high-intensity focused ultrasound thrombolysis guided by ultrasound imaging in experimental settings. METHODS AND RESULTS A therapeutic transducer was constructed from an acoustic lens and integrated with an ultras...

Formations of acoustic cavitation bubbles in various resonator set−ups are recorded by high− speed stereoscopic means. The bubble distributions and motions are reconstructed in three dimensions. Such data is a key for better understanding of the mechanisms taking place in applications of intense ultrasound in liquids. Furthermore, the data serves for verification and improvement of particle mod...

background: our previous studies revealed an inhibitory effect of icd-85 (venom derived peptides) on mda-mb231 and hl-60 cell lines, through induction of apoptosis. the purpose of this study was to investigate apoptosis-induced mechanism on hela and mrc-5 cells by icd-85 through activation of caspase-8. methods: cell viability, cytosolic enzyme lactate dehydrogenase (ldh) and cell morphology we...

Several emerging therapies with potential for use in the brain, harness effects produced by acoustic cavitation--the interaction between ultrasound and microbubbles either generated during sonication or introduced into the vasculature. Systems developed for transcranial MRI-guided focused ultrasound (MRgFUS) thermal ablation can enable their clinical translation, but methods for real-time monit...

Abstract Punica granatum peel is a significant source of polyphenolic compounds that have potential uses as drugs. This study aimed to obtain and purify derived from pomegranate evaluate their anticancer activity in cell lines. Polyphenols the were extracted using hybrid ultrasound‐microwave technology. Different mass:volume ratios water:ethanol used during extraction. Purification was performe...

OBJECTIVES Currently available fetal intervention techniques rely on invasive procedures that carry inherent risks. A non-invasive technique for fetal intervention could potentially reduce the risk of fetal and obstetric complications. Pulsed cavitational ultrasound therapy (histotripsy) is an ablation technique that mechanically fractionates tissue at the focal region using extracorporeal ultr...

Methods Ten craniectomized pigs where sonicated with an ExAblate4000 Neuro (InSightec, Haifa, Israel) operated with a 220Hz array made of 1024 transducers. For each animal, a thermal lesion was aimed on the right thalamus, while a cavitation (mechanical) lesion was aimed on the contralateral side. For thermal lesioning, 40s duration sonications were performed and the acoustical energy ranged be...