The early bi-potential mammalian gonad requires the expression of a Y-linked gene, Sry, during a brief window of time to ensure proper testis development. WT1 and its direct target gene Sf1 function during sex determination as well as in the specified testes and ovaries. We have previously shown that the transcription co-factor CITED2 interacts with WT1 to stimulate the expression of Sf1 in the...

The Wilms' tumor suppressor gene, Wt1, encodes a transcription factor critical for development of the urogenital system. To identify lineages within the developing urogenital system that have a cell-autonomous requirement for Wt1, chimeric mice were generated from Wt1-null ES cells. Males with large contributions of Wt1-/- cells showed hypoplastic and dysgenic testes, with seminiferous tubules ...

The embryonic development of germ cells in tetrapods is described, focusing on groups with the inductive mode of germ cell specification. In mammals PGCs are induced early in the gastrulation process, they are internalized with future extraembryonic mesoderm in the early posterior primitive streak, and specified soon thereafter. Strong evidence indicates that a similar process occurs in turtles...

Autoimmune gonad destruction was induced in Atlantic salmon of both sexes in trials carried out on fish kept in sea cages on a fish farm. Damage to gonads was only found in fish where the first injection of gonad extract had been given together with Complete Freund's Adjuvant, injections without adjuvant or with carrageenan as an adjuvant were unsuccessful. Length and weight differences between...

The aim of this study was to identify periods in zebrafish (Danio rerio) development when estrogen exposure has long-term consequences on reproductive capabilities at the adult stage. To this end, zebrafish were exposed to 10 ng/L ethynylestradiol (EE(2)) during three stages of gonadal differentiation: (i) the juvenile hermaphroditic stage when gonads display the morphology of an immature ovary...

Aquatics are a source of bioactive compounds that these compounds have different properties such as antimicrobial activity. In this study, antibacterial activity of methanol, chloroform and hexane extracts from body wall, gonad and intestine of sea cucumber Holothuria leucospilota was evaluated against Bacillus subtilis, Pseudomonas aeruginosa and Staphylococcus aureus. Bioactive compounds of b...

During development, complex organs are formed from individual cells and simple tissues. Organogenesis is characterized by many cellular behaviors, including cell migration, modification of cell contacts, changes in cell shape, cell proliferation and cell death. Extensive communication between cells ensures that different cell types act together in a coordinated manner to form a properly pattern...

The study on the biological aspects of Charybdis hellerii (A. Milne-Edwards, 1867) in world and Indonesia were very limited. This aims to measure sex ratio, gonad development, carapace width body weight relationship, condition factor, first size sexual maturity, fecundity. was conducted from July September 2020 western Tiworo Strait, South Konawe, SoutheastSulawsei. C. samples bycatch blue swim...

Sudhausia aristotokia n. gen., n. sp. and S. crassa n. gen., n. sp. (Nematoda: Diplogastridae): viviparous new species with precocious gonad development Matthias HERRMANN 1, Erik J. RAGSDALE 1, Natsumi KANZAKI 2 and Ralf J. SOMMER 1,∗ 1 Max Planck Institute for Developmental Biology, Department of Evolutionary Biology, Spemannstraße 37, Tübingen, Germany 2 Forest Pathology Laboratory, Forestry ...

46, XY complete gonadal dysgenesis (Swyer syndrome) is a rare cause of 46, XY sexual development disorder. The patient presented to our clinic with absence of breast development and lack of periods at the age of 17 years. Her history and familial history involved no relevant conditions. She had Tanner stage 1 thelarche, and Tanner stage 2 pubic hair development with no axillary hair development...