The aim of this study was to investigate the antitumor effect of a plasmid co-expressing ENDO-VEGI151 and survivin siRNA on breast cancer in nude mice, and to explore the feasibility of attenuated Salmonella typhimurium (S. typhimurium) as a delivery vector for cancer gene therapy in vivo. Three recombinant expression plasmids pENDO‑VEGI151 (pEV), pSurvivin-siRNA (psi-survivin) and co-expressin...

The origin of the fermion generations is discussed. A strong interactions spin IS is introduced which unifies the quarks and leptons as two multiplets of this spin. The electroweak vector bosons and gluons emerge as the fused states of these fermion multiplets. We discussed the possibility of existence of the electroweak spin quantum number IW = 1 2 for all fermions besides their space time spi...

Abstract Background Serrated lesions (SLs), including sessile serrated (SSL) and traditional adenomas (TSA) have become subject of increased interest for their role as CRC precursors. Purpose Study aim was to evaluate the risk develop total metachronous advanced neoplasia (T-MAN) at follow-up in patients with index SL compared a matched cohort without SL. Method Patients 45-74y SLs were identif...