Manasse was first reported cholesterol granuloma of the middle ear in 1917. Shambaugh in 1929 described idiopathoc hemotympanum as a cause to the development of cholesterol granuloma of middle ear. Cholesterol granuloma have been seen in multiple area of the human body where cholesterol crystals may exist such as the lungs, breasts, peritoneum, mediastinum, liver, spleen, thyroid, kidneys, lymp...

Multiple immune factors control host responses to Mycobacterium tuberculosis infection, including the formation of granulomas, which are aggregates of immune cells whose function may reflect success or failure of the host to contain infection. One such factor is TNF-α. TNF-α has been experimentally characterized to have the following activities in M. tuberculosis infection: macrophage activatio...

Granuloma annulare is a benign inflammatory skin lesion of unknown etiology that is usually seen in adults and children and subtypes of it includes localized granuloma annulare, generalized granuloma annulare, subcutaneous granuloma annulare and arcuate dermal erythema. Etiology and pathogenesis of granuloma annulare are obscure, although there is much evidence for an immunologic mechanism. Pre...

Definition Pyogenic granuloma (PG) is a common reactive neoformation of the oral cavity, which is composed of granulation tissue and develops in response to local irritation or trauma. Various different names have been given to this entity, reflecting, in part, mistaken concepts about its aetiopathogenesis: • Botryomycosis hominis • Botryomycoma • Telangiectatic granuloma • Benign pedunculated ...

Granuloma formation and its regulation are dependent on lymphocytes. Therefore, we compared the characteristics of lymphocytes derived from the spleens and granulomas of Schistosoma mansoni-infected mice during the course of their disease. We examined lymphocyte cell cycle kinetics, migration, expression of activation Ags (CD69 and IL-2R), cytokine production (IL-2, IL-4, IFN-gamma), and apopto...

Naked sarcoidal granulomas are supposedly characteristic, but not pathognomonic of sarcoidosis. Other types of histopathological pattern can also happen in sarcoidosis and may lead to misdiagnosis. Thirteen archival skin specimens taken from 10 patients were retrieved from our fi le for study. All patients were labeled as sacroidosis based on histological evidence of noncaseating granuloma foun...

Eosinophilic granuloma was formerly mistaken for “eosinophilic myeloma” (Finzi 1929) or for “osteomyelitis with eosinophilic reaction” (Schairer 1938). It was described as a new distinct entity by Otani and Ehrlich (1940) under the denomination solitary granuloma of bone and by Jaffe and Lichtenstein (1944) as eosinophilic granuloma ofbone. Farber(l94l) and Green and Farber (1942) showed that e...

Pyogenic granuloma-like Kaposi sarcoma (PG-like KS) is a clinicopathologic variant of (KS), vascular tumor caused by human herpesvirus-8 (HHV-8). PG-like KS challenging entity to diagnose because its clinical and histological features encompass both pyogenic granuloma (PG) Distinction between the two entities clinically important as management different. patients requires evaluation their immun...

granuloma annulare is self-limiting cutaneous condition of unknown etiology, causing necrobiotic dermal and subcutaneous papules. a number of conditions have been described in association with granuloma annulare , including lymphoma, anemia, intestinal bleeding, seronegative arthralgia, vasculitis and autoimmune thyroiditis. this manuscript, as the first report of this combination in iran, desc...

central giant cell granulomas (cgcgs) may manifest as radiolucencies anywhere in the mandible or maxilla. in rare cases, it can appear as a localized periradicular area and mimic an endodontic lesion. this case report presents an uncommon location of cgcg which was not accurately diagnosed nor timely treated. periodic follow ups of periapical radiolucencies after rct are necessary. dentists sho...