This study was designed to investigate the effects of dietary onion flesh or onion peel on lipid peroxides and DNA damage in aged rats. Sprague Dawley male rats (n=40, 16 mo old) were blocked into five groups and raised for 3 mo with either an onion-free control diet or onion diets (Allium cepa L., intermediate-day variety) containing either 5% (w/w) powdered dried onion flesh, 5% (w/w) powdere...

Chemical peels have been time-tested and are here to stay. Alpha-hydroxy peels are highly popular in the dermatologist's arsenal of procedures. Glycolic acid peel is the most common alpha-hydroxy acid peel, also known as fruit peel. It is simple, inexpensive, and has no downtime. This review talks about various studies of glycolic acid peels for various indications, such as acne, acne scars, me...

this study was designed to investigate the effects of tangerine, orange, and grapefruit juice on the pharmacokinetic pattern of cyclosporine a in rats. forty male sprague-dawley rats were divided into four groups to receive water, orange, tangerine, or grapefruit juices respectively. water or juices (10 ml/kg) were given orally twice a day for 3 days. three hours after the 5 th dose, cyclospori...

Concomitant administration of grapefruit juice can increase the plasma concentration of numerous drugs in humans and decrease the concentration of a few others. Such elevations of drug plasma concentrations have, on occasion, resulted in adverse clinical effects. Increased concentrations are primarily mediated by chemicals in grapefruit juice, which inhibit the CYP 3A4 drug-metabolizing enzyme ...

To establish the most convenient and effective method to dry tangerine peels, different methods (sun drying, hot-air drying, freeze drying, vacuum drying, and medium- and short-wave infrared drying) were exploited. Our results indicated that medium- and short-wave infrared drying was the best method to preserve nutraceutical components; for example, vitamin C was raised to 6.77 mg/g (D.W.) from...

The computer graphic simulation of a common spray painting artifact, called orange peel, is discussed. Orange peel distorts surface reflections and is commonplace in product design applications. The orange peel measurements from a standard industrial instrument are used to construct a height field, and this surface is rendered using traditional normal mapping techniques. Comparisons are made be...

tramadol is a centrally acting analgesic drug extensively metabolized in animal species. its clinicalresponse is mainly due to the m1 metabolite, poorly produced in dogs. grapefruit-juice can inhibit themetabolism of different drugs in animals and humans. the aim of the present study was to evaluate thepharmacokinetics of tramadol and its major metabolites after co-administration of tramadol an...

Putrescine (Put) increased 68% in lemon (Citrus limon (L.) Burm. f. cv Bearss) flavedo, 39% in grapefruit (C. paradisi Macf. cv Marsh) flavedo, 49% in grapefruit juice, and 149% in pepper (Capsicum annuum L. cv Early Calwonder) pericarp when fruits were stored at chilling temperatures. In lemon flavedo, the coefficient of correlation (r(2)) between Put concentration with severity of chilling wa...

In the last few years a lot of reports dealt with pharmacokinetic interactions leading to elevated cyclosporine (CsA) blood concentrations. These interactions involve various drugs and food constituents, including antibiotics, antifungal agents, calcium antagonists, dietary lipids, and grapefruit juice.1,2 Grapefruit juice has been shown to significantly inhibit the gut wall cytochrome P 450 is...