نتایج جستجو برای: grn reverse engineering models
تعداد نتایج: 1233163 فیلتر نتایج به سال:
In many areas of industry, it is desirable to create geometric models of existing objects for which no such model is available. This paper reviews the process of reverse engineering of shapes. After identifying the purpose of reverse engineering and the main application areas, the most important algorithmic steps are outlined and various reconstruction strategies are presented. Pros and cons of...
Introduction Frontotemporal lobar degeneration-causing mutations in the progranulin (GRN) gene reduce progranulin protein (PGRN) levels, suggesting that restoring PGRN in mutation carriers may be therapeutic. Nimodipine, a Food and Drug Administration-approved blood-brain barrier-penetrant calcium channel blocker, increased PGRN levels in PGRN-deficient murine models. We sought to assess safety...
Progranulin (PGRN), a secreted growth factor, is a key regulator of inflammation and is genetically linked to two common and devastating neurodegenerative diseases. Haploinsufficiency mutations in GRN, the gene encoding PGRN, cause frontotemporal dementia (FTD), and a GRN SNP confers significantly increased risk for Alzheimer's disease (AD). Because cellular and animal data indicate that increa...
In business processes, companies have found an ally to improve their competitiveness. The performance of these companies depends on their information systems, which may have evolved separately from the business processes. In order to align the legacy systems and the business processes, it is necessary to recover the current business processes hidden in legacy systems. Reverse engineering toward...
most of river engineering problems are complicated and need to be analyzed by three dimensional models of flow and sediment transport. considering the fact that computers and numerical methods with great ability of flow and sediment transport simulation are developing quickly, using numerical modeling by engineers is inevitable. nevertheless, before application, numerical models need to be veri...
Maintenance and evolution of complex software systems (such as mobile telephones) involves activities such as reverse engineering (RE) and software visualization. Although several RE tools exist, we found their architecture hard to adapt to the domain and problem specific requirements posed by our current practice in Nokia. In this paper, we present an open architecture which allows easy protot...
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