Approximately 15 different alpha, or CXC, chemokines have thus far been isolated from 11 species of mammals. Among the best studied chemokines are the 12 human proteins that are encoded by 11 paralogous genes. In order to better understand the evolution and function of this group of genes, we isolated and characterized six novel GRO and GRO-related cDNA sequences from the cow (Bos taurus), the ...

An Asynchronous Gated Ring Oscillator based Time to Digital Converter (A-GRO-TDC) is proposed. Gating functionality is added to a simple Ring Oscillator which drastically improves the system performance with asynchronous operation. Energy saving is possible due to scrambling and first order noise shaping. The proposed 9 bit A-GRO-TDC is implemented in Cadence using 0. 18μm digital CMOS Technolo...

Eukaryotic gene expression is regulated both at the transcription and the mRNA degradation levels. The implementation of functional genomics methods that allow the simultaneous measurement of transcription (TR) and degradation (DR) rates for thousands of mRNAs is a huge improvement in this field. One of the best established methods for mRNA stability determination is genomic run-on (GRO). It al...

chemokines are classified in four distinct groups as cxc, cc, cx3c and c, depending on the presence or absence of a motif called elr (arg-leu-glu) before the first cysteine residue in their structure. cxc chemokines are also subdivided into elr + and elr - . increasing evidence has indicated the existence of a chemokine network in the liver which is involved in both physiological responses and,...

© 2015 The Authors. This is an Open Access article. Traditionally, senescence in plants is defined as internally programmed degeneration or age-related declines in survival and reproduction, leading to death or variation in mortality patterns ��oach 200��. �lants �ith indeterminate gro�th, such as clonal plants or bryophytes, may escape determinacy of death or aging by continuous gro�th �ith pr...

In promoting a "New Policy Agenda," bilateral and multilateral donor agencies are keen to finance nongovernmental organizations (NGOs) and grassroots organizations (GROs) on the grounds of their economic efficiency and contribution to "good governance." This paper reviews the impact of this trend on NGO/GRO programming, performance, legitimacy and accountability. It finds that much of the case ...

An 80MS/s analog-to-digital converter (ADC) based on single-slope conversion is presented which utilizes a recently developed gated ring oscillator (GRO) time-to-digital converter (TDC) to achieve an ENOB of 6.45 bits. To save power, the time-to-digital conversion is done in two steps, the first of which is based on coarse time quantization as measured by cycles of an oscillator and the second ...