نتایج جستجو برای: guanosine
تعداد نتایج: 18281 فیلتر نتایج به سال:
The yeast YLR209c (PNP1) gene encodes a protein highly similar to purine nucleoside phosphorylases. This protein specifically metabolized inosine and guanosine. Disruption of PNP1 led to inosine and guanosine excretion in the medium, thus showing that PNP1 plays an important role in the metabolism of these purine nucleosides in vivo.
The kinetics of reduced triphosphopyridine nucleotide oxidation suggested that guanosine 5’.diphosphate-n-mamrose was converted to intermediates before reduction by reduced triphosphopyridine nucleotide (2). Subsequent studies revealed that the intermediates could be chemically reduced to guanosine 5’-diphosphate-6-deoxyhexoses (3). The present paper is concerned with the nature of the intermed...
Purine metabolism in Giardia lamblia was investigated by monitoring incorporation of radiolabeled precursors into purine nucleotides in the log-phase trophozoites cultivated in vitro in axenic media and incubated in buffered saline glucose. The lack of incorporation of formate, glycine, hypoxanthine, inosine, and xanthine into the nucleotide pool suggests the absence of de novo purine nucleotid...
Growing evidence implicates CD40, a member of the TNFR superfamily, as contributing to the pathogenesis of many neurodegenerative diseases. Thus, strategies to suppress its expression may be of benefit in those disorders. To this aim, we investigated the effect of guanosine, a purine nucleoside that exerts neurotrophic and neuroprotective effects. CD40 expression and function are increased by e...
• De novo synthesis but also uptake of nucleosides is essential for bacterial cell viability . Lipoprotein PnrA the only known pneumococcal substrate binding protein nucleosides. The 3-D structure deciphered in complex with five plasticity to adapt differences between purine- and pyrimidine-based In vivo experiments reveal implications virulence. Nucleotides are important RNA DNA and, despite a...
Title of Dissertation: SYNTHETIC ION CHANNELS FROM LIPOPHILIC GUANOSINE DERIVATIVES Ling Ma, Doctor of Philosophy, 2009 Dissertation directed by: Professor Jeffery T. Davis Department of Chemistry and Biochemistry Synthetic ion channels and pores not only represent models of natural transmembrane ion channels, but also demonstrate their potential applications in the areas of drug delivery, bios...
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