Kernicterus is known to produce damage to the auditory system and the basal ganglia in humans. Although the Gunn rat model of kernicterus has been extensively used to characterize the auditory features, this model has not been similarly utilized to systematically investigate the movement disorder. In the present study, spontaneously jaundiced (jj) 16 day old Gunn rat pups were treated with sulf...

Mildly elevated bilirubin is associated with a reduction in the presence and progression of chronic kidney disease and related mortality, which may be attributed to bilirubin's antioxidant properties. This study investigated whether endogenously elevated bilirubin would protect against adenine-induced kidney damage in male hyperbilirubinaemic Gunn rats and littermate controls. Animals were oral...

Isolated surgical lesions were made in three Macaca mulatta monkeys. Two had right optic tract section. One control underwent section of the right half of the chiasm. Preoperative evaluation revealed no fundus, pupil, or VER abnormalities. Postoperatively, a classic Marcus Gunn pupil was found contralateral to the isolated optic tract lesions. The control had normal pupils. The nature of the le...

1. Vitamin D deficiency was induced in anicteric Wistar rats, Wistar rats before common bile-duct ligation was performed and Gunn rats with unconjugated hyperbilirubinaemia. 2. The effect of ultraviolet radiation on plasma concentrations of 25-hydroxy-vitamin D was studied in a group of control anicteric Wistar rats (n = 11), Wistar rats 8 days after common bile-duct ligation (n = 7) with conju...

CONGENITAL ptosis in association with jaw-winking is a clinical entity in which the ptosis disappears and the lid retracts on opening the mouth, or on moving the jaw to the opposite side. This condition, known as the Marcus Gunn phenomenon (Gunn, 1883), has been noted in association with paralysis of the superior rectus (Proskauer, 1891; Goldzeiher, 1892), internal rectus (Uhthoff, 1888), exter...

THE Gunn rat is an animal model for Crigler-Najar syndrome. a rare form of congenital unconjugated nonhemolytic hyperbilirubinemia due to the absence of glucoronyl transferase. I.e It leads to deposition of bilirubin in the basal ganglia. culminating in precocious death of the patient. Because the uptake. conjugation. and excretion of bilirubin by hepatocytes involves specific carriers and enzy...

Two t>pes of active antenna elements have been studiedexperimentally One type uses a mkrostrip antenna with an active devicemounted directlv on the antenna. The other uses an active device coupledlo a microstrip patch antenna through an aperture. Microstrip activeantenna elements and two-element arrays have been demonstrated for bothtypes of circuits. Injection locking of th...

The dynamics of a system comprising of two bilaterally coupled Gunn oscillators (BCGOs) has been examined using a circuit theoretic model of the Gunn oscillator (GO). The effects of coupling factors (kij ) between i-th and j-th oscillators on the frequency-range of synchronized operation and the magnitude of common frequency of oscillation have been examined semi-analytically and by numerical s...

Contributing Authors: Robert M. Sapolsky, Ph.O., Stanford University, John A. Gunn, Ph.O., Stanford University, Cynthia Fry Gunn Ph.O.,Stanford University, Allan Siegel, Ph.O., New lersey Medicai 5chool, lordan Grafman, Ph.O., Rehabilitation Institute of Chicago, Pamela Blake, M.D., Memorial Hermann Northwest Hospital, Peter K. Hatemi, Ph.O., Pennsylvania State University, Rose McOermott, Ph.O....