Detection of lung cancer at an early stage is necessary for successful therapy and improved survival rates. We performed a bottom-up proteomics analysis using a two-dimensional LC-MS/MS strategy on the conditioned media of four lung cancer cell lines of different histological backgrounds (non-small cell lung cancer: H23 (adenocarcinoma), H520 (squamous cell carcinoma), and H460 (large cell carc...

Ionic channel activity is involved in fundamental cellular behaviour and participates in cancerous features such as proliferation, migration and invasion which in turn contribute to the metastatic process. In this study, we investigated the expression and role of voltage-gated sodium channels in non-small-cell lung cancer cell lines. Functional voltage-gated sodium channels expression was inves...

Mitochondrial dysregulation is closely associated with excessive reactive oxygen species (ROS) production. Altered redox homeostasis has been implicated in the onset of several diseases including cancer. Mitochondrial DNA (mtDNA) and proteins are particularly sensitive to ROS as they are in close proximity to the respiratory chain (RC). Mitoquinone (MitoQ), a mitochondria-targeted redox agent, ...

Agricultural support has changed substantially in both rich and poor countries recent years. In countries, there been a strong move to decoupled subsidies fall average rates of protection. developing market price remains the dominant form protection, have risen—breaking traditional pattern taxing agriculture. Emissions from agriculture land use change contributed up third total greenhouse gas e...

Thermotolerant yeasts are widely considered to be alternative strains traditional for bioethanol production at high temperatures. In this study, thirty-two isolated from lychees were screened thermotolerance, and seven selected isolates identified as Candida tropicalis (isolates H8, H19, H23), Meyerozyma guilliermondii H1 H12) Saccharomyces cerevisiae H10 H18). They tolerated up 45 °C, 12% (v/v...

The ecological literature suggests that biodiversity reduces the variance of ecosystem services. Thus, conservative biodiversity management has an insurance value to risk-averse users of ecosystem services. We analyze a conceptual ecological-economic model in which such management measures generate a private benefit and, via ecosystem processes at higher hierarchical levels, a positive external...

In a multi-country model with mobile capital and global pollution this paper analyzes the stability of self-enforcing environmental agreements (IEAs) when the coalition formed by the signatory countries plays Nash. In accordance with previous environmental literature we show that there exists a unique self-enforcing IEA consisting of two or three signatory countries if emissions tax rates are s...

This paper proposes a dynamic politico-economic theory of intergenerational contracts, whose driving force is the intergenerational conflict over government spending. Embedding a repeated probabilistic voting setup in a standard OLG model with human capital accumulation, we find that the empowerment of elderly constituencies is key in order to enforce productive policies. The paper characterize...