The design of bioactive scaffolds with improved mechanical and biological properties is an important topic of research. This paper investigates the use of polymer-ceramic composite scaffolds for bone tissue engineering. Different ceramic materials (hydroxyapatite (HA) and β-tri-calcium phosphate (TCP)) were mixed with poly-ε-caprolactone (PCL). Scaffolds with different material compositions wer...

Current clinical strategies for adipose tissue engineering (ATE), including autologous fat implants or the use of synthetic surrogates, not only are failing in the long term, but also can't face the latest requirements regarding the aesthetic restoration of the resulted imperfections. In this context, modern strategies in current ATE applications are based on the implantation of 3D cell-scaffol...

Objective(s): Adipose tissue is one of the most important endocrine organs that liberates many metabolic mediators such as hormones, cytokines, and chemokines. Different types of fatty acids have key roles in adipogenesis. The aim of this study was to evaluate the effects of two essential fatty acids, including Arachidonic acid (AA) and Eicosapentaenoic acid (EPA), on ...

Polycaprolactone (PCL) is one of the most recognized polymeric materials used for bone tissue engineering scaffold fabrication. This study aims to evaluate effects molecular weight (Mn) PCL on degradation kinematics, surface, microstructural, thermal, mechanical, and biological properties 3D printed scaffolds. Surface were investigated considering water-in-air contact angle nanoindentation test...

BACKGROUND The reconstruction of adipose tissue defects is often challenged by the complications that may occur following plastic and reconstructive surgery, including donor-site morbidity, implant migration and foreign body reaction. To overcome these problems, adipose tissue engineering (ATE) using stem cell-based regeneration strategies has been widely explored in the last years. Mounting ev...

Modifications of biomaterials based on the combination physical, chemical, and biological cues for manipulating stem cell growth are needed modern regenerative medicine. The exploitation these sophisticated modifications remains a challenge, including substrate limitation, biocompatibility, versatile general activities. In this report, vapor-phase coating technique functionalization poly-p-xyly...

In tissue engineering, excessively generated reactive oxygen species (ROS) during biomaterial implantation or cell transplantation is a one of major causes diminishing therapeutic effects. this study, we prepared surfaces coated with antioxidant epigallocatechin gallate (EGCG) and metal ions, evaluated their anti-oxidative ROS scavenging properties. We revealed that EGCG-coating on polycaprolac...

In recent years, there has been an increasing interest in interactive application principles of biology and engineering for the development of valid biological systems for tissue regeneration, such as for the treatment of bone fractures or skeletal defects. The application of stem cells together with biomaterials releasing bioactive factors promotes the formation of bone tissue by inducing prol...