BACKGROUND To pical minoxidil solution 2% stimulates new hair growth and helps stop the loss of hair in men with androgenetic alopecia and women with female pattern hair loss. Results can be variable, and historic experience suggests that higher concentrations of topical minoxidil may enhance efficacy. OBJECTIVE The purpose of this 48-week, double-blind, placebo-controlled, randomized, multic...

Eflornithine 11.5% cream is an effective treatment for unwanted facial hair (UFH) in women with the effect on facial hair growth starting to be seen from 1 month after treatment initiation. TrichoScan is a validated method of assessing hair length, thickness, density, and growth rate using contact skin microscopy. The study aimed to evaluate the efficacy of eflornithine cream in women with UFH,...

A plethora of growth factors regulate keratinocyte proliferation and differentiation that control hair morphogenesis and skin barrier formation. Wavy hair phenotypes in mice result from naturally occurring loss-of-function mutations in the genes for TGF-alpha and EGFR. Conversely, excessive activities of TGF-alpha/EGFR result in hairless phenotypes and skin cancers. Unexpectedly, we found that ...

M any studies have investigated hair removal or growth prevention treatments, but they often measure hair density using noninvasive methods that are subjective and qualitative. Although photographic and digital hair-counting methods have been used, their reliability and validity remain unknown. We describe a simple, noninvasive method of hair counting used in a hair growth prevention treatment ...

BACKGROUND Androgens are thought to have an adverse effect on female scalp hair growth. However, our clinical experience of androgen replacement therapy in women with androgen deficiency, in which hair loss was seldom reported, led us to question this concept. OBJECTIVES To evaluate the effect of subcutaneous testosterone therapy on scalp hair growth in female patients. METHODS A total of 2...

P lant root hairs are experimental model systems for research on plant cell growth. The involvement of protons and reactive oxygen species (ROS) in root hair growth and development has been the subject of significant research effort (e.g., refs. 1–4). pH specifically has been implicated in the control of plant cell expansion (5), including that in root hair cells (6). ROS have recently come to ...

BACKGROUND Microneedle is a method that creates transdermal microchannels across the stratum corneum barrier layer of skin. No previous study showed a therapeutic effect of microneedle itself on hair growth by wounding. OBJECTIVE The aim of this study is to investigate the effect of repeated microwound formed by microneedle on hair growth and hair growth-related genes in a murine model. MET...

Insect wax is secreted by Ericerus pela Chavanness. It has been traditionally used to treat hair loss in China, but few reports have been published on the hair growth-promoting effect of insect wax. In this work, we examined the hair growth-promoting effects of insect wax on model animals. Different concentrations of insect wax were topically applied to the denuded backs of mice, and 5% minoxid...