Severity of depression, as reflected by total scores on depression rating scales, has been established as one of several major sources of variance associated with hypothalamic-pituitary-adrenal axis dysregulation in patients with major depressive disorder. To determine which of the symptoms comprising clinically defined severity of illness contribute most to this relationship, we studied the as...

CONTEXT Alternative and over-the-counter medicines have become increasingly popular choices for many patients who prefer not to take traditional antidepressants. The adrenal androgen and neurosteroid dehydroepiandrosterone (DHEA) is available as over-the-counter hormonal therapy and previously has been reported to have antidepressant-like effects. OBJECTIVE To evaluate the efficacy of DHEA as...

objective : patients with chronic physical diseases sometimes show increased loss of function; such patients need more care. anxiety is a well-known symptom that is prevalent among chronic obstructive pulmonary disease patients that can prolong and increase the risk of hospitalization. the purpose of this study was to evaluate the severity of anxiety in the mentioned patients and to examine the...

BACKGROUND Hedonic tone and its absence, anhedonia, are important in psychopathological research, but instruments for their assessment are lengthy and probably culturally biased. METHOD A new scale was constructed from the responses of a large sample of the general population to a request to list six situations which afforded pleasure. The most frequent items were reviewed and those likely to...

This study compared two measures of depression in a population with schizophrenia. Inpatients (n = 112) with schizophrenia, were assessed on the Hamilton (HDRS), and Calgary (CDSS) depression scales and the Positive and Negative Syndrome Scale (PANSS). Eighty-nine were reassessed 3 months later. A principal components factor analysis was applied to each depression scale. The relationship betwee...

OBJECTIVE Preliminary studies have indicated that daily left prefrontal repetitive transcranial magnetic stimulation might have antidepressant activity. The authors sought to confirm this finding by using a double-blind crossover design. METHOD Twelve depressed adults received in random order 2 weeks of active treatment (repetitive transcranial magnetic stimulation, 20 Hz at 80% motor thresho...

Patients: 184 people aged 18–65 years with somatisation disorder, undifferentiated somatoform disorder, and somatoform autonomic dysfunction (somatic subscore of the Hamilton Anxiety Scale (HAMA-SOM) .12 and the psychic subscore (HAMA-PSY) of 5 points below HAMA-SOM). For inclusion, participants required a Somatoform Disorders Screening Instrument (SOM) SOMS-2 (number of 53 conditions present i...

We report the case of a 53-year-old Chinese woman who presented with symptoms of depression, anxiety, feelings of agitation, irritability, hyperhidrosis, slow action and decreased interest in most activities. Computed tomography of the brain revealed intracranial calcification, scores on the Hamilton Anxiety Scale and Hamilton Depression Scale showed that she suffered from depression and anxiet...

We analyze the photometric redshift catalog of the Sloan Digital Sky Survey Data Release 5 (SDSS DR5) to estimate the Fisher information in the galaxy angular power spectrum with the help of the Rimes-Hamilton technique. It is found that the amount of Fisher information contained in the galaxy angular power spectrum is saturated at lensing multipole scale 300 ≤ l ≤ 2000 in the redshift range 0....

Background and Purpose The aim of the study was to investigate the efficacy and safety of the selective serotonin reuptake inhibitor citalopram in treating poststroke depression, since available treatments are usually poorly tolerated. Methods A 6-week double-blind, placebo-controlled trial was undertaken. Diagnosis and outcome were determined using the Hamilton Depression Scale, and unwanted e...