Head and neck squamous cell carcinomas (HNSCC) are common human malignancies with poor clinical outcomes. The 5-year survival rates for patients with advanced stage HNSCC have not changed appreciably in the past few decades, underscoring a dire need for improved therapeutic options. Recent studies have elucidated a key signaling axis, the EGFR-STAT3-Bcl-XL signaling axis, that is aberrantly act...

Note: An invasive epithelial neoplasm with varying degrees of squamous differentiation that arises from the following anatomic sites: the oral cavity, particularly oral soft tissues including the gingival and alveolar mucosa, floor of the mouth, tongue, soft and hard palates, tonsils and oropharynx. Oral squamous cell carcinomas (SCC) have a propensity to early and extensive lymph node metastases.

Objective: Squamous cell carcinoma (SCC) is a life threatening lesion but there has been only limited research about its frequency in Iran. The aim of this study was to evaluate the frequency of squamous cell carcinoma of the head and neck in the records of the pathology department of Imam Khomeini hospital in Ahvaz between 2005 and 2015. Methods: The retrospective and cross-sectional study was...

Large and comprehensive genomic surveys of head and neck squamous cell carcinomas (HNSCC) are now greatly increasing our understanding of the diversity of this disease and the key genomic changes that drive these tumors. The results from these studies are beginning to inform the introduction of novel therapies for patients with HNSCCs. Here, we review some of the key findings from recent genomi...

statement of the problem: the head and neck region is an uncommon site for metastatic involvement, but it can be the first and only symptom of primary cancer. the incidence of these tumors and their primary origins are limited in iranian patients. purpose: therefore, this retrospective study aimed to investigate the frequency and the common related clinical manifestations, as well as, the most ...

Abstract Background Micro-RNAs (miRNAs) have been reported as an emerging biomarker in many cancer types. They are used diagnostic and prognostic biomarkers could be considered therapeutic targets treating the same. Main body Studies proven that miRNAs play essential role molecular pathophysiology, including oral squamous cell carcinoma. Distinct expression profiles of different demonstrated Am...

Numerous studies have investigated the risk of cancer associated with the polymorphism of p21 3' UTR (rs1059234 C > T), but results have been inconsistent. We performed this meta-analysis to drive a more precise estimation of the association between this polymorphism and risk of cancer. A comprehensive search was conducted to identify all case-control studies of the rs1059234 C > T polymorphism...

BACKGROUND Cytarabine is the most effective agent known for the treatment of acute myeloid leukemia. Its antitumor effect is expressed by combining with DNA during replication and then destroying the DNA chain. However, cytarabine has only limited activity against most solid tumors, including squamous cell carcinoma of the head and neck. The reason for this is thought to be that in cell lines o...

Squamous cell carcinoma head and neck is the sixth most common cancer worldwide and.[1] Multimodality therapies have been advocated for locoregional relapse or metastatic disease.[2] Combination therapy with lenvatinib has considered to overcome resistance improve efficacy.[3] In a recent study of pembrolizumab conducted in heavily pretreated recurrent cancer, median overall survival OS was 6.2...

This article discusses the value of 18F-fluoro-2-deoxyglucose PET/CT imaging biomarkers in head and neck squamous cell carcinoma. 18F-fluoro-2-deoxyglucose PET/CT is valuable at baseline staging, radiotherapy planning, therapy response assessment and in the follow-up of patients with head and neck squamous cell carcinoma. Maximum and peak standardized uptake value (SUVmax and SUVpeak), metaboli...