BACKGROUND In cognitively impaired patients without dementia, the utility of apolipoprotein E (APOE) genotyping is unclear. OBJECTIVE To evaluate the predictive utility of the APOE epsilon4 genotype for conversion to probable Alzheimer disease (AD). DESIGN Naturalistic, longitudinal study. SETTING Memory disorders outpatient clinic. PATIENTS A total of 136 patients with memory complaint...

Basal cell carcinoma is the most common type of cancer in fair-skinned individuals, and its incidence is rapidly increasing. The aim of the present study was to investigate the gene and protein expression of the mitochondrial solute carrier family 25 member 43 (SLC25A43) in basal cell carcinoma. SLC25A43 has previously been identified to be genetically altered and associated with cell prolifera...

INTRODUCTION AND OBJECTIVES Streptococcus pneumoniae (SP) is a human pathogen that involves a high use of antibiotics. The objective of the study was to determine the susceptibility to commonly used antibiotics and their associated risk factors, in order to promote rational use of antibiotics. PATIENTS AND METHODS In A multicentre study was conducted in summer 2009 and winter 2010 on children...

Frontotemporal dementia (FTD) is the second commonest form of dementia after Alzheimer's disease, but its clinical and biological features are less well known. To uncover its earliest signs, we studied the main clinical, neuroimaging, and biochemical findings in an asymptomatic carrier from a three generation FTD family, bearing the P301L pathogenic mutation in the tau gene. Except for selectiv...

Poultry are commonly infected with a wide variety of salmonella serovars and infection is generally subclinical (Wray et al., 1996). Poultry farming is often hampered by reduction in productivity due to infections with large number of bacteria, salmonellosis being the most important causing great economic losses due to mortality and reduction in egg production (Khan et al., 1998). Under the new...

Non-invasive biological indicators of the absence/presence or progress of the disease that could be used to support diagnosis and to evaluate the effectiveness of treatment are of utmost importance in Duchenne Muscular Dystrophy (DMD). This neuromuscular disorder affects male children, causing weakness and disability, whereas female relatives are at risk of being carriers of the disease. A biom...

The diagnosis of invasive pneumococcal disease (IPD) is currently based on culture methods, which lack sensitivity, especially after antibiotic therapy. Molecular methods have improved sensitivity and do not require viable bacteria; however, their use is complicated by reports of low specificity with some assays. The present study investigated the specificity of a real-time PCR targeting lytA f...

Genetic diseases devastate the society. Out of 9 million birth defects 7.9 are due to genetic causes. Management of most of the inherited disorders are very expensive and not affordable to majority. Early detection and lifelong therapy is mandatory. Palliative nature of the treatments available prolongs lives resulting in accumulation of cases and cost escalation. Therefore prevention is mandat...

The data on biologic effects of nonthermal microwaves (MWs) from mobile telephones are diverse, and these effects are presently ignored by safety standards of the International Commission for Non-Ionizing Radiation Protection (ICNIRP). In the present study, we investigated effects of MWs of Global System for Mobile Communication (GSM) at different carrier frequencies on human lymphocytes from h...