To the Editor:—We read with great scientific interest the study of Vuyk et al. reporting three cases in which volunteers receiving combinations of propofol and midazolam remained responsive to verbal command although the Bispectral Index (BIS) values were at, or just above, 40, the area considered to be associated with adequate hypnosis for surgery (BIS, 40–60). Vuyk et al. note that the electr...

objective(s): crocin is the chemical ingredient primarily responsible for the color of saffron. it has different pharmacological effects such as antioxidant, anticancer and memory improving activities. crocin tablets were evaluated for short-term safety and tolerability in healthy adult volunteers. materials and methods: the study was a randomized, double-blind, placebo-controlled design consis...

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This study investigates motilin effects on the proximal stomach in patients with functional dyspepsia (FD) and healthy volunteers. Eight healthy volunteers and 12 patients with FD were infused with synthetic motilin or placebo. Proximal gastric volume was measured with a barostat at constant pressure and during isobaric distensions. Abdominal symptoms were scored by visual analog scales. Plasma...

BACKGROUND AND PURPOSE Dilated perivascular spaces have been shown to be a specific biomarker of cerebral small-vessel disease in young patients with dementia. Our aim was to examine the discriminative power of dilated cerebral perivascular spaces as biomarkers of small-vessel disease in a very elderly population of patients with dementia. MATERIALS AND METHODS We studied healthy volunteers (...